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Medicine Drugs

Medicine - Xagena Medical News

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Aggiornamento in Medicina

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Teflaro for the treatment of adults with community acquired bacterial pneumonia and acute bacterial skin and skin structure infections: FDA approved

The FDA ( Food and Drug Administration ) has approved Teflaro ( Ceftaroline fosamil ), an injectable antibiotic to treat ...
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Restless legs syndrome: FDA has approved Horizant

The FDA ( Food and Drug Administration ) has approved Horizant Extended Release Tablets ( Gabapentin enacarbil ), a once-daily ...
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The first vaccine to prevent meningococcal disease in children as young as 9 months: FDA has approved Menactra

The FDA ( Food and Drug Administration ) has approved the use of Menactra in children as young as 9 ...
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Pregnancy: maternal use of proton pump inhibitors is linked to increased risk of cardiac birth defects

The use of common anti-reflux medications, proton pump inhibitors ( PPIs ), during pregnancy may be associated with cardiac birth ...
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Women with HER2+ breast cancer: Pertuzumab and Trastuzumab combination improves efficacy

The phase II study results of the NeoSphere neoadjuvant trial has shown that the combination of Trastuzumab ( Herceptin ) ...
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Everolimus, new indication: treatment of patients with subependymal giant cell astrocytoma associated with tuberous sclerosis

The FDA ( Food and Drug Administration ) approved Afinitor ( Everolimus ) to treat patients with subependymal giant cell ...
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Eltrombopag reduces bleeding, and increases platelet levels in idiopathic thrombocytopenic purpura

New data from two long-term studies ( RAISE: 197 patients and EXTEND: 144 patients ) have shown that patients with ...
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Ofatumumab: high response rates in patients with Fludarabine- and Alemtuzumab-refractory chronic lymphocytic leukemia

The study enrolled patients with chronic lymphocytic leukemia ( CLL ), heavily pre-treated, who did not respond to, or who ...
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NICE does not recommend Ofatumumab as a treatment for refractory chronic lymphocytic leukaemia

The NICE ( National Institute for Health and Clinical Excellence ) has published three separate pieces of guidance for the ...
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NICE recommends Denosumab as a treatment option for certain postmenopausal women who are at increased risk of osteoporotic fractures

NICE ( National Institute for Health and Clinical Excellence ) recommends a range of treatment options for reducing the risk ...
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Idiopathic thrombocytopenic purpura: NICE does not recommend Eltrombopag

In final guidance published by NICE ( National Institute for Health and Clinical Excellence ) Eltrombopag ( Revolade ) is ...
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Levetiracetam, Topiramate and Vigabatrin may increase risk of suicide

While the FDA ( Food and Drug Administration ) is requiring a warning of an increased risk of suicide for ...
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Pazopanib, positive results in the treatment of advanced renal cell carcinoma and ovarian cancer

GlaxoSmithKline ( GSK ) has announced results from ongoing Phase II studies of Pazopanib ( Votrient ) in advanced or ...
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Diabetes mellitus: FDA has restricted access to Avandia

The FDA ( Food and Drug Administration ) announced that it will significantly restrict the use of the diabetes drug ...
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Cetuximab does not add significant benefit to the NORDIC FLOX regimen in first-line treatment of metastatic colorectal carcinoma

Adding the targeted drug Cetuximab ( Erbitux ) to a three-drug chemotherapy regimen for first-line treatment of metastatic colorectal cancer ...
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Iniparib improves overall survival in metastatic triple-negative breast carcinoma

Women with an aggressive subtype of metastatic breast cancer appear to live an average of almost five months longer when ...
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Advanced neuroendocrine tumors: Afinitor delays tumor progression

The results of a large Phase-III clinical trial have shown that the drug Everolimus ( Afinitor ) delays tumor progression ...
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Panitumumab fails to add overall survival benefit in recurrent, metastatic head and neck cancer

Adding the monoclonal anti-EGFR antibody Panitumumab ( Vectibix ) to chemotherapy did not significantly improve overall survival for patients with ...
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Pazopanib shows promise in relapsed, refractory urothelial cancer

An ongoing Phase-II trial investigating Pazopanib ( Votrient ) for metastatic urothelial cancer has generated promising early results. Urothelial cancers affect ...
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Abiraterone improves survival in metastatic castration-resistant prostate cancer

Patients with metastatic castration-resistant prostate cancer who have progressed after chemotherapy live significantly longer if treated with the drug Abiraterone ...
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Newly diagnosed ovarian cancer: Bevacizumab reduces the risk of disease progression during the first year of treatment

Adding Bevacizumab ( Avastin ) to chemotherapy as a treatment for newly diagnosed ovarian cancer reduces the risk of disease ...
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Afatinib improves progression-free in lung adenocarcinoma patients whose cancer progressed after treatment with EGFR inhibitors

Lung cancer patients who have already been treated with the EGFR inhibitors Erlotinib or Gefitinib seem to gain further benefits ...
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Triple negative breast cancer: adding Cetuximab to chemotherapy doubles response rate

Targeting the epidermal growth factor receptor can provide substantial clinical benefit for women with hard-to-treat triple-negative breast cancer. A Phase-II randomized ...
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MLN8237, an investigational drug shows promise against ovarian cancer resistant or refractory to Platinum-based chemotherapy

Researchers at Dana-Farber Cancer Institute in the USA reported the results of the single-agent trial of the drug, called MLN8237, ...
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Advanced non-small cell lung cancer: benefits for some patients adding MetMAb to Erlotinib

A subset of lung cancer patients seem to live longer and experience delays in disease progression when a new drug ...
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Gefitinib does not improve overall survival in patients with advanced NSCLC with EGFR activating mutations

Data from the IPASS study showed that overall survival ( OS ) was similar, with no significant difference, between Gefitinib ...
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Rheumatoid arthritis: B cell depletion with anti-CD20

B cells, precursors of autoantibody-secreting cells, have emerged as promising new therapeutic targets in autoimmune diseases, including rheumatoid arthritis ( ...
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Chronic idiopathic thrombocytopenic purpura: long-term treatment with oral Eltrombopag

A double-blind, multicenter, phase III study found that long-term Eltrombopag ( Promacta, Revolade ), therapy compared with placebo treatment significantly ...
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Rituximab and Dexamethasone compared to Dexamethasone alone in idiopathic thrombocytopenic purpura

A phase III study is the first to prospectively determine that adding Rituximab ( MabThera, Rituxan ) to Dexamethasone is ...
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Osteoarthritis of the hip or knee: Glucosamine and Chondroitin do not work

Two supplements taken by millions of people around the world to combat joint pain do not work, finds research published ...
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FDA: Actos and potential increased risk of bladder cancer after two years exposure

L’FDA ( Food and Drug Administration ) is reviewing data from an ongoing, ten-year epidemiological study designed to evaluate whether ...
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Drugs for anxiety or insomnia increase mortality risk by 36 percent

Taking medications to treat insomnia and anxiety increases mortality risk by 36%, according to a study conducted by Belleville, at ...
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Acute coronary syndrome: safety of two intravenous Heparin doses as adjunct to PCI in patients treated with Fondaparinux

Results from the FUTURA/OASIS 8 study provide initial evidence that a low dose of unfractionated Heparin does not reduce the ...
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Metastatic renal-cell carcinoma: switch to metronomic chemotherapy could offer new treatment option

A new multi-targeted chemo-switch drug regimen shows promising anti-tumour activity with manageable side effects in patients with metastatic renal-cell carcinoma ...
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EINSTEIN DVT trial: Rivaroxaban is an effective and safe treatment for acute symptomatic deep vein thrombosis

Results of the Phase III EINSTEIN-DVT study have shown that the oral anticoagulant Rivaroxaban ( Xarelto ) achieved the primary ...
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ANTIPAF trial: sartans do not reduce the number of AF episodes in patients with paroxysmal atrial fibrillation and without structural heart disease

Atrial fibrillation ( AF ) is a progressive chronic disease in which episodes become more frequent and long-lasting over time. ...
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AVERROES trial: Apixaban reduces risk of stroke and systemic embolism in atrial fibrillation

The phase 3 AVERROES ( Apixaban Versus Acetylsalicylic acid to Prevent Strokes ) trial, designed to show the superiority of ...
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Advanced kidney cancer: Sorafenib shrinks tumor prior to surgery

Physicians who conducted a pilot study at University of North Carolina ( UNC ) Lineberger Comprehensive Cancer Center found that ...
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Chronic myeloid leukaemia: a vaccine made with leukemia cells may reduce or eliminate the last remaining cancer cells

Preliminary studies by Researchers at Johns Hopkins Kimmel Cancer Center, have shown that a vaccine made with leukemia cells may ...
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Mirena LNG-IUS appears to prevent the development of benign endometrial polyps in breast carcinoma patients taking Tamoxifen

Adjuvant Tamoxifen ( Nolvadex ) reduces the risk of breast cancer recurrence in women with estrogen receptor-positive breast carcinoma. Tamoxifen ...
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Abatacept for rheumatoid arthritis: moderate-level evidence regarding efficacy and safety

Abatacept ( Orencia ) inhibits the co-stimulation of T cells and disrupts the inflammatory chain of events that leads to ...
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Vitamin-D supplementation for cystic fibrosis: no evidence of benefit or harm

Cystic fibrosis is a genetic disorder with multiorgan effects. In a subgroup with pancreatic insufficiency malabsorption of the fat soluble ...
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SAMe for osteoarthritis of the knee or hip: routine use should not be advised

Osteoarthritis is the most common form of joint disease and the leading cause of pain and disability in the elderly. ...
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Type 1 Gaucher disease: Vpriv approved in Europe

European Commission has granted marketing authorisation for Vpriv ( Velaglucerase alfa ), a human cell line derived enzyme replacement therapy ...
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Dasatinib and Nilotinib: phase III clinical trials show improved responses over Imatinib

Two drugs approved for treatment of drug-resistant chronic myeloid leukemia ( CML ) provide patients with quicker, better responses as ...
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Treatment-resistant bipolar disorder: Ketamine reduces symptoms of depression within 40 minutes

A single intravenous dose of the anesthetic agent Ketamine appears to reduce symptoms of depression within 40 minutes among those ...
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Advances in renal cell carcinoma management

Renal cell carcinoma ( RCC ) accounts for about 3% of all solid tumours in adults, and worldwide, more than ...
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Psoriasis drugs: a comparison between Etanercept and Ustekinumab

Researchers at The University of Manchester ( UK ) have compared the drugs Etanercept ( Enbrel ) and Ustekinumab ...
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FDA has received reports of malignancies in children using TNF antagonists

The FDA ( Food and Drug Administration ) has received reports of malignancies in children using tumor necrosis factor alpha ...
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REDUCE trial: Dutasteride in the prevention of prostate tumor

An editorial about REDUCE ( Reduction by Dutasteride of Prostate Cancer Events ) trial by Fritz H Schröder and Monique ...
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Dutasteride reduces risk of prostate carcinoma diagnosis in high-risk men

Dutasteride ( Avodart ) has shown to reduce the risk of a prostate cancer diagnosis by 23 percent in men ...
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Doxycycline should not be recommended for the treatment of osteoarthritis of the knee or hip

Osteoarthritis is a chronic joint disease that involves degeneration of articular cartilage. Pre-clinical data suggest that Doxycycline might act as ...
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Acute postoperative pain in adults: single dose oral Ketoprofen and Dexketoprofen

Ketoprofen is a non-selective non-steroidal anti-inflammatory drug ( NSAID ) used to treat acute and chronic painful conditions. Dexketoprofen is ...
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Chronic neuropathic pain in adults: topical Capsaicin

Topical creams with Capsaicin are used to treat pain from a wide range of chronic conditions including neuropathic pain. Following ...
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Diabetic macular oedema: antiangiogenic therapy with Bevacizumab

Diabetic macular oedema is a common complication of diabetic retinopathy. The retina at the macula thickens and this can cause ...
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Formoterol versus Salmeterol for chronic asthma: serious adverse events

An increase in serious adverse events with both regular Formoterol and regular Salmeterol in chronic asthma has been demonstrated in ...
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Olmesartan increases risk of death

The FDA ( Food and Drug Administration ) has not concluded that Olmesartan ( Benicar ) increases the risk of ...
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Ticagrelor more effective than Clopidogrel in myocardial infarction patients

New research has shown that the stronger anticlotting medication Ticagrelor ( Brilinta ) reduces death rates without increasing bleeding compared ...
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Sartans: higher incidence of lung tumor

Sartans, or Angiotensin-receptor blockers, are a class of blood-pressure-lowering drug that is also used for the treatment of heart failure ...
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Epilepsy: Levetiracetam, Topiramate and Vigabatrin may increase risk of suicide

A new study has shown that only certain epilepsy drugs may increase the risk of suicide. The study is published ...
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Atypical antipsychotics among older adults with dementia: FDA warnings linked to reduced use

The use of atypical antipsychotics to treat elderly patients with dementia appears to have decreased following a 2005 FDA ( ...
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Modified-release oral opioids of the WHO level III scale for the management of pain: benefits of most of these medicines outweigh risks

The EMA ( European Medicines Agency ) has finalised a review of modified-release oral opioids of the WHO level III ...
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Some anticonvulsants may be linked to increased risk of suicide

Data of an analysis of prescription and clinical claims suggests that the use of certain anticonvulsant medications may be associated ...
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FDA: new recommendations on the appropriate use of LABAs in the treatment of asthma

Long-acting beta-agonists ( LABAs ), a class of medications used for the treatment of asthma and chronic obstructive pulmonary disease ...
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Pediatric patients: use of antipsychotics associated with significant weight gain

Many pediatric and adolescent patients who received second-generation antipsychotic medications experienced significant weight gain, along with varied adverse effects on ...
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Tibolone increases risk of recurrence in breast tumor survivors

Tibolone ( Livial ), a synthetic steroid used to treat menopausal symptoms and to prevent osteoporosis, significantly increases the risk ...
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Rotarix: porcine circovirus type 1 in the oral vaccine poses no risk to public health, according to EMA

Following a review of the oral vaccine Rotarix, the European Medicines Agency’s Committee for Medicinal Products for Human Use ( ...
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EMA is reviewing benefit-risk balance of Avandia, Avandamet and Avaglim

The EMA ( European Medicines Agency ) is currently reviewing Rosiglitazone to determine the impact of new data from recent ...
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EMA: Modafinil for treatment of narcolepsy only

The EMA ( European Medicines Agency ) has recommended restricting the use of Modafinil-containing medicines. The medicine should only be ...
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EMA: positive benefit-risk balance of topical formulations of Ketoprofen

Following a review of topical formulations of Ketoprofen, the European Medicines Agency’s Committee for Medicinal Products for Human Use ( ...
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Parkinson's disease: Stalevo linked to possible development of prostate carcinoma

The FDA ( Food and Drug Administration ) is evaluating clinical trial data that may suggest that patients taking Stalevo, ...
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Sartans linked to risk of cancer

Angiotensin-receptor blockers ( also known as sartans ) are a widely used drug class approved for treatment of hypertension, heart ...
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High-dose Simvastatin associated with increased risk of muscle injury

Based on review of data from a large clinical trial and data from other sources, the FDA ( Food and ...
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Olmesartan linked to cardiovascular events

The FDA ( Food and Drug Administration ) is evaluating data from two clinical trials in which patients with type ...
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Angiotensin receptor blockers linked to tumor: FDA is conducting a safety review

The FDA ( Food and Drug Administration ) is conducting a review of the class of medications known as angiotensin ...
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Meridia is contraindicated in patients with history of cardiovascular disease or uncontrolled hypertension

The FDA ( Food and Drug Administration ) has reviewed additional data that indicate an increased risk of myocardial infarction ...
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HIV infection: Saquinavir in combination with Ritonavir linked to abnormal heart rhythm

The FDA ( Food and Drug Administration ) is reviewing clinical trial data about a potentially serious effect on the ...
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Zyprexa: use in adolescents and safety informations

The FDA ( Food and Drug Administration ) has approved the use of oral Zyprexa ( Olanzapine ) in adolescents ...
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Increase in risk of diabetes and cardiovascular diseases in men treated with GnRH agonists

GnRH ( Gonadotropin-Releasing Hormone ) agonists, a class of drugs primarily used to treat men with prostate cancer, have been ...
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Postmenopausal breast cancer: role of bisphosphonates

Bisphosphonates are routinely given to women with postmenopausal breast cancer, but new data suggests that these agents may play a ...
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Head and neck tumor: Cetuximab increases survival for up to 5 years

Adding Cetuximab ( Erbitux ) to radiation therapy prolongs survival in patients with locally advanced head and neck cancer compared ...
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Acetylsalicylic acid use after colorectal tumor diagnosis associated with improved survival

Men and women with colorectal cancer and began regular use of Acetylsalicylic acid ( Aspirin ) had a lower risk ...
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Renal cell carcinoma: interventional cryoablation is effective

Freezing kidney tumors should be the gold standard or first treatment option for all individuals with tumors that are 4 ...
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Advanced non-small cell lung cancer: Vandetanib has shown clinical benefit when combined with Docetaxel

When combined with standard chemotherapy, Vandetanib ( Zactima ) improves progression-free survival for patients with advanced non-small cell lung cancer. The ...
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Acute myeloid leukaemia: Pfizer has voluntarily withdrawn Mylotarg

Pfizer has announced the voluntary withdrawal from the US market of the drug Mylotarg ( Gemtuzumab ozogamicin ) for patients ...
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Hedgehog inhibitor yields positive response in people with advanced basal cell skin cancer and with medulloblastoma

The Hedgehog signaling pathway is involved in a preliminary study and case report describing positive responses to an experimental anticancer ...
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Myocardial infarction: patients treated with more antithrombotics have increased risk of hospital admission for bleeding

In patients with myocardial infarction, risk of hospital admission for bleeding increases with the number of antithrombotic drugs used. Patients ...
Leggi articolo

Acute coronary syndromes: Ticagrelor, a better option than Clopidogrel for patients undergoing invasive procedures

A new research has shown that Ticagrelor ( Brilinta ) reduces death rates without increasing bleeding compared with the current ...
Leggi articolo

Methylprednisolone added to Interferon beta-1a reduces relapse rate in patients with relapsing-remitting multiple sclerosis

Addition of oral Methylprednisolone to standard treatment of subcutaneous Interferon beta-1a substantially reduces the relapse rate in patients with relapsing-remitting ...
Leggi articolo

Progressive multifocal leukoencephalopathy: JC virus is found to be reactivated in multiple sclerosis patients receiving Natalizumab

The virus responsible for PML ( progressive multifocal leukoencephalopathy ), a rare brain disease that typically affects AIDS patients and ...
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EGFR mutations in non-small-cell lung cancer: Gefitinib improves survival compared with standard chemotherapy

Patients with the most common form of lung cancer, non-small-cell lung cancer, who have mutations in the epidermal growth factor ...
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Advanced kidney cancer: Sunitinib shows promising results in patients with poor prognosis

Sunitinib ( Sutent ) prolongs progression-free and overall survival, and is safe and well tolerated in advanced kidney cancer ( ...
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Inoperable hepatocellular carcinoma: Lapatinib shows minimal effect

Use of Lapatinib ( Tykerb ) to delay tumor growth and improve the survival of patients with inoperable hepatocellular carcinoma, ...
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Sorafenib improves progression free survival in patients with breast cancer

In the advanced breast cancer, one study has found that if Sorafenib ( Nexavar ) is combined with the chemotherapy ...
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Bevacizumab improves hearing in some patients with neurofibromatosis type 2

Treatment with the angiogenesis inhibitor Bevacizumab ( Avastin ) improved hearing and alleviated other symptoms in patients with neurofibromatosis type ...
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Bevacizumab is no different in effectiveness as Ranibizumab, the gold standard treatment for age-related macular degeneration

Researchers from Boston University School of Medicine ( BUSM ) and the VA Boston Healthcare System have shown, at 6 ...
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CT imaging may predict survival in patients with metastatic colorectal cancer treated with Bevacizumab

Using routine computed tomography ( CT ) imaging to analyze form and structural changes to colorectal liver metastasis after Bevacizumab ...
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Head and neck cancer: Cetuximab continues to increase survival in patients for up to 5 years

Adding Cetuximab ( Erbitux ) to radiation therapy prolongs survival in patients with locally advanced head and neck cancer compared ...
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Colorectal cancer with inoperable metastatic liver lesions: addition of Cetuximab to chemotherapy increases tumor shrinkage

Adding Cetuximab ( Erbitux ) to neoadjuvant chemotherapy can shrink tumours leading to increased potentially curative surgery in patients who ...
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Rituximab reduces inflammation in patients with lupus nephritis

Treatment with Rituximab can significantly benefit some patients with severe lupus nephritis who do not respond to conventional therapy, according ...
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