A University of Minnesota Cancer Center study is the first to show how the prevalence of some physical impairments that childhood-cancer survivors experience as adults relate to the type of cancer they had and the treatment they received.

The findings indicate long-term follow up care and physical rehabilitation may be important for more than 20 percent of childhood-cancer survivors.

This study of nearly 11,500 childhood-cancer survivors is published in the Annals of Internal Medicine.

Kirsten Ness, at University of Minnesota Cancer Center and led the research team on this study, analyzed information reported by 11,481 survivors enrolled in The Childhood Cancer Survivor Study, an ongoing follow-up study of survivors of childhood cancer coordinated by the University of Minnesota.

These survivors were treated for primary brain cancer, leukemia, Hodgkin disease, non-Hodgkin's lymphoma, kidney tumor, neuroblastoma, and soft-tissue sarcoma or malignant bone cancer before age 21 and had survived at least five years after diagnosis.
Their information was compared to that provided by 3,839 siblings of childhood-cancer survivors.

" Overall, we found that about 20 percent of the survivors had physical limitations and trouble performing activities of daily living, such as running, climbing stairs, bending, lifting, stooping, walking, eating or dressing," Ness says. " But, almost 40 percent of survivors of bone tumors and 30 percent of survivors of brain tumors reported having these difficulties." According to Ness, survivors of brain and bone cancers were most likely to report physical limitations and difficulty doing routine activities to the point of limiting their ability to attend work or school.
Brain cancer survivors also were most likely to report difficulty with performing personal care.

She notes that survivors who received radiation therapy or a combination of radiation therapy and chemotherapy were more likely to have difficulty than survivors treated with surgery alone.

" The findings of this study indicate that medical side effects occurring later in life and interfering with physical ability are common after treatment of childhood cancer," Ness says.

Source: University of Minnesota, 2005


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