Preeclampsia, the development of high blood pressure and protein in the urine during pregnancy and its more severe complications such as eclampsia, can threaten the lives of both mother and child. While there is no therapy to prevent preeclampsia, a link to calcium deficiency has been suggested.
A study, published in the American Journal of Obstetrics and Gynecology, investigated whether a Calcium supplement could reduce the complications and mortality from preeclampsia.
Over 8300 women with low dietary calcium ( <600 mg/day, about half of that recommended during pregnancy ) were selected for the study.
The subjects were randomly divided into two groups that had similar gestational ages, demographic characteristics, and normal blood pressures before treatment started.
Half were given 1.5g of a Calcium supplement per day and half received a placebo.

While the incidence of preeclampsia was not statistically different in the supplemented women, eclampsia, other severe complications and severe gestational hypertension were significantly lower. Overall, the " severe preeclamptic complications index " and the " severe maternal morbidity and mortality index, " including all severe conditions, were also reduced with Calcium.

Preterm and early preterm delivery ( <32 weeks ) tended to be reduced among women who were at highest risk for low calcium and complications. It is very important to note that neonatal mortality was also lower in the Calcium group.

Writing in the article, Jose Villar, states, " This large randomized trial in populations with low calcium intake demonstrates that while supplementation with 1.5 gm Calcium/day did not result in a statistically significant decrease in the overall incidence of preeclampsia, Calcium significantly decreased the risk of its more serious complications, including maternal and severe neonatal morbidity and mortality, as well as preterm delivery, the latter among young women."

Source: American Journal of Obstetrics and Gynecology, 2006


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