Infections could contribute to adult brain tumours

A British and Dutch team analysed a database of adult brain tumours diagnosed in patients from the North Brabant province ...

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Warfarin increases risk of bone fracture

Elderly patients taking the commonly prescribed Warfarin ( Coumadin ), an anticoagulant medication, experience an increased risk for osteoporosis-linked bone ...

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Angiopoietin-2, a new player in sepsis-associated acute respiratory distress syndrome

A study by Vikas Sukhatme and colleagues, at the Beth Israel Deaconess Medical Center and Harvard Medical School, has ...

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Major cardiovascular damage: modified troponin I protein improves heart function

Researchers from the University of Michigan ( U-M ) Medical School suggest this amino acid, called histidine, could be the ...

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Coronary artery disease: Rosuvastatin may reverse atherosclerosis

A two-year study demonstrated that Rosuvastatin ( Crestor ) reversed plaque build-up in the arteries of patients with evidence of ...

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Trauma to the aorta causes cognitive loss following coronary artery bypass surgery

Minimizing trauma to the aorta, during heart bypass surgery can significantly reduce cognitive loss that often follows the operation, a ...

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Protein MDC1 amplifies DNA injury signals

A Mayo Clinic-led research collaboration has discovered that the protein MDC1 amplifies weak DNA injury signals so genetic repair can ...

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CBFB-SMMHC, an oncoprotein, induces abnormal preleukemic blood cell progenitors

Researchers have developed a novel mouse model for leukemia that reveals critical information about the mechanisms involved in leukemia progression ...

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Urine test helps detect 99 percent of recurring bladder cancers

A simple urine test that can be interpreted in a doctor's office can help detect nearly all recurrences of bladder ...

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Bexarotene is a potential lung cancer preventative with few side effects

Researchers at Washington University School of Medicine in St. Louis reported that a compound related to vitamin A shows promise ...

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HPV DNA testing is a cost-effective strategy for women with equivocal cervical screening results

A study has found that using human papillomavirus ( HPV ) DNA testing to determine who should receive a cervical ...

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Study CAPRIE: Moxifloxacin more effective at treating elders' pneumonia

An antibiotic medication, Moxifloxacin ( Avelox ), proved more effective at knocking out community-acquired pneumonia ( CAP ) in patients ...

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Fitness counteracts cognitive decline from hormone-replacement therapy

Women pondering hormone-replacement therapy also should consider regular exercise. A study at the University of Illinois at Urbana-Champaign suggests that ...

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Genetically modified lactic acid bacteria to prevent HIV infection

Researchers have come up with a novel delivery system for anti-AIDS drugs: milk-curdling bacteria used to make yogurt and cheese. ...

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Gardasil, a new vaccine for prevention of cervical cancer in females caused by human papillomavirus

The FDA ( Food and Drug Administration ) has approved Gardasil, the first vaccine developed to prevent cervical cancer, precancerous ...

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Spinocerebellar ataxia type 5 caused by mutations in the protein beta-III spectrin

Researchers at the University of Minnesota Medical School have discovered the gene responsible for a type of ataxia, an incurable ...

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Technique for multiplying adult stem cells developed

Researchers of the Whitehead Institute have discovered a way to multiply an adult stem cell 30-fold, an expansion that offers ...

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Malaria parasites develop in lymph nodes

Researchers at the Pasteur Institute in Paris found the malaria parasite Plasmodium developing in an unexpected place: the lymph nodes. The ...

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Genetic predisposition may raise risk of Emanuel syndrome

A report, published in the journal Science by researchers at The Children's Hospital of Philadelphia and the University of Pennsylvania ...

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NovoSeven for intracerebral hemorrhage: a promising therapy

Intracerebral hemorrhage accounts for up to 15 percent of the 750,000 strokes that occur annually in the United States, says ...

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HIV/AIDS trial: continuous antiretroviral therapy superior to episodic therapy

The enrollment into a large international HIV/AIDS trial comparing continuous antiretroviral therapy with episodic drug treatment guided by levels of ...

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Map of part of adult human brain containing astrocytes released

A study led by a Johns Hopkins researcher has provided the first comprehensive map of a part of the adult ...

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K-Ras can be manipulated to promote cell death

A study led by New York University School of Medicine researchers has discovered a protein widely known to cause the ...

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Farnesyltransferase inhibitor may improve progeria

Researchers at UCLA ( University of California – Los Angeles ) found that an experimental cancer drug improves the signs ...

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Sensible metabolic differences in how adults, infants and children process drugs

A Medical College of Wisconsin study provides the strongest evidence to date of major changes occurring during human development in ...

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Rad9 as a potential target for cancer therapy

Researchers at Washington University School of Medicine in St. Louis found that inactivating a protein called mammalian Rad9 could make ...

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Bismacine may cause serious adverse events

The FDA ( Food and Drug Administration ) warns consumers and healthcare professionals not to use a product called Bismacine, ...

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Wine drinkers have healthier diets than beer drinkers

Studies have shown that drinking wine is associated with lower mortality than drinking beer or spirits. Some studies have also ...

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CDK4 as a targeted approach to treating aggressive breast cancers

Researchers at Dana-Farber Cancer Institute have identified a molecular interaction that triggers a particularly aggressive form of breast cancer, and ...

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Wet age-related macular degeneration: FDA has approved Lucentis

The FDA ( Food and Drug Administration ) has approved Lucentis ( Ranibizumab injection ) for the treatment of patients ...

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HIV-1 infection: FDA has approved Atripla, an once-a-day three-drug combination

The FDA ( Food and Drug Administration ) has approved Atripla, a fixed-dose combination of three widely-used antiretroviral drugs, in ...

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Fingolimod: sustained efficacy over 18 months in patients with relapsing multiple sclerosis

Data from the extension of a Phase II study to 18 months support the significant effects of FTY720 ( Fingolimod ...

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Botox as an adjuvant to cancer therapy

A study, published in the Clinical Cancer Research, has showed that Botox may have a new use as an adjuvant ...

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Healthy preterm infants show reduced lung function

Tests of healthy preterm infants younger than 12 weeks of age showed prematurity to be independently associated with reduced lung ...

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Smokers: supplements of vitamin C can stop the serious depletion of vitamin E

A study has found that supplements of vitamin C can largely stop the serious depletion of vitamin E that occurs ...

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New test could help in diagnosing shaken baby syndrome

Researchers at Children's Hospital of Pittsburgh have found that increased levels of certain proteins in the blood or spinal fluid ...

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Ovarian cancer responds to Aspirin derivative with Cisplatin

A study using ovarian cancer cell lines showed promise in treating tumor by combining the chemotherapy drug Cisplatin with an ...

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WHI: a small but significant 1 percent higher hip bone density for women taking calcium combined with vitamin D

The results of a major clinical trial, part of the Women’s Health Initiative ( WHI ) found that calcium and ...

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tPA-ultrasound combination increases reopening of blocked arteries after stroke

A pilot study led by University of Cincinnati researchers showed that standard clot-busting medication combined with low-energy ultrasound appears ...

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Training benefits brains in older people

A research at the University of Illinois at Urbana-Champaign showed that training re-ignites key areas of the brain, offsetting some ...

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FDA has approved Sprycel in chronic myeloid leukemia and Ph+ acute lymphoblastic leukemia, with resistance to prior therapy

The FDA ( Food and Drug Administration ) has approved Sprycel ( Dasatinib ), an oral inhibitor of multiple ...

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Huntington's disease: Tetrabenazine may cut down involuntary movements

Tetrabenazine ( Nitoman/Xenazine ) cut down involuntary movement in patients with Huntington's disease on average by about 25 percent, with ...

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Calcium and Vitamin D slightly decrease risk of hip fractures in older women

Women's Health Initiative ( WHI ) found that taking Calcium and Vitamin D slightly decreased the risk of hip fractures ...

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Omega-3 fatty acids are unlikely to reduce the risk of cancer

A review of studies found no strong evidence indicating a significantly reduced risk of cancer associated with the consumption of ...

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Carbon monoxide poisoning: heart injury increases long-term risk of death

Of patients who were hospitalized and treated for moderate to severe carbon monoxide poisoning, those who sustained heart muscle injury ...

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Parkinson’s disease: Exelon for treatment of dementia

The FDA ( Food and Drug Administration ) has approved Exelon ( Rivastigmine ) for the treatment of mild to ...

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Wet age-related macular degeneration: FDA has approved Lucentis

The FDA ( Food and Drug Administration ) has approved Lucentis ( Ranibizumab ) for the treatment of patients with ...

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Bipolar disorder in children and teens is different from adults

Children and teenagers with bipolar disorder suffer from the illness differently than adults do. Their symptoms last longer and swing ...

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Levitra may protect the heart following acute myocardial infarction

Researchers at Virginia Commonwealth University ( VCU ) found that Levitra ( Vardenafil ), an erectile dysfunction drug, protects ...

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Mangafodipir may improve cancer-killing ability of chemotherapy

Mangafodipir, a contrast agent currently used in magnetic resonance imaging ( MRI ), may increase the cancer-killing ability of some ...

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Antioxidant supplementation not associated with decreased risk of prostate cancer

Intakes of dietary or supplemental antioxidants were not associated with a decreased risk of prostate cancer among men in the ...

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Morphine and topical Tetracaine found effective in treating pain in newborn infants

Intravenous Morphine used alone or with topical Tetracaine effectively reduced levels of pain in preterm newborn infants undergoing central line ...

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Tetrabenazine is effective to treat the excessive involuntary movements of Huntington’s

A drug dramatically eases one of the most disabling symptoms of Huntington’s disease, involuntary writhing movements known as chorea. The medication ...

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A study finds four in 10 myocardial infarctions go unrecognised

Dutch researchers who assessed over 4,000 men and women over 55 to see how many myocardial infarction went undiagnosed at ...

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Non-BRCA hereditary breast cancer linked to new cancers

The risk for a new cancer in the unaffected breast substantially increases in women diagnosed with unilateral, hereditary ( non-BRCA ...

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X chromosome abnormalities contribute to the pathogenesis of basal-like breast cancers

Basal-like breast cancers ( BLC ) are highly aggressive tumors with a relatively poor prognosis that account for approximately 15% ...

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Small molecules overcome drug resistance in cancers associated with high-risk viruses

Treatment of human cancer is often impeded when cancer cells develop resistance to drugs that are designed to induce a ...

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Diuretics reduce risk of death from congestive heart failure

A study has shown that diuretics reduce the risk of death, delay heart deterioration and improve exercise capacity in patients ...

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Major depression, electroconvulsive therapy improves quality of life for at least six months

Electroconvulsive therapy ( ECT ) improves quality of life in patients with major depression, and that improved quality of life ...

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Stroke, few patients get to hospital in time for treatment

Few people who are having a stroke get to the hospital in time to receive the clot-busting drug that reduces ...

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Asthma, older adult patients have increased cancer risk

A study has showen that older adults with asthma are at an increased risk for developing cancer, and adults with ...

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Thrombolitic therapy before angioplasty or stent placement not beneficial for myocardial infarction patients

Despite the lack of evidence for its safety and effectiveness, many doctors believe the practice of giving patients with sudden ...

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Infectious agents pose new risks for people with bleeding disorders

A team of researchers has concluded that people with bleeding disorders such as hemophilia remain at risk from emerging infectious ...

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Safety and efficacy of Risedronate for the treatment of male osteoporosis

A Phase III trial has evaluated the safety and efficacy of Risedronate ( Actonel ) for male osteoporosis. In the trial, ...

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Seasonal affective disorder: FDA has approved Wellbutrin XL

The FDA ( Food and Drug Administration ) has approved Wellbutrin XL for prevention of major depressive episodes in patients ...

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Advanced cervical cancer: FDA has approved a combination of Hycamtin and Cisplatin

The FDA ( Food and Drug Administration ) has approved a combination of Hycamtin ( Topotecan ) and Cisplatin for ...

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NICE recommends Herceptin for early breast cancer

NICE has recommended Herceptin ( Trastuzumab ) for women with early stage HER2-positive breast cancer, except where there are concerns ...

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Multiple sclerosis: BG-12 reduces number of gadolinium-enhancing brain lesions

A Phase II study evaluated the efficacy and safety of BG-12, an oral Fumarate, in patients with relapsing-remitting multiple sclerosis. The ...

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Combination of Vildagliptin and Pioglitazone in patients with type 2 diabetes

Vildagliptin ( Galvus ), a new once-daily oral treatment option for type 2 diabetes, has demonstrated efficacy, especially in patients ...

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Exenatide: sustained improvements in blood glucose control and progressive weight loss after two years

A two-year study has shown that Exenatide ( Byetta ) injection sustained improvements in blood glucose control and reduced body ...

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Gardasil for prevention of cervical cancer and other diseases in females caused by HPV

The FDA ( U.S. Food and Drug Administration ) has approved Gardasil, the first vaccine developed to prevent cervical cancer, ...

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Type 2 diabetes, Sitagliptin reduces blood glucose levels in monotherapy or as add-on treatment

Phase III studies demonstrated that Sitagliptin ( Januvia ), an investigational oral, once-daily medicine for type 2 diabetes, significantly reduced ...

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Ruboxistaurin reduces the risk of vision loss caused by diabetic retinopathy

Results from an analysis of pooled data from two, three-year phase 3 trials showed that Ruboxistaurin ( Arxxant ) ...

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Acetylsalicylic Acid reduces cardiovascular risks in men and women, but differently

A meta-analysis of more than 95,000 patients has shown that Acetylsalicylic Acid ( Aspirin ) can significantly reduce the ...

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Variations in growth-factor gene linked to risk of prostate cancer

Researchers from the Keck School of Medicine of the University of Southern California, the Broad Institute of Harvard and MIT, ...

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Alzheimer's disease linked to abnormal cell division

A study in mice suggests that Alzheimer's disease may be triggered when adult neurons try to divide. The study is published ...

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Tenecteplase-facilitated PCI in patients with ST-segment elevation acute myocardial infarction is not recommended

Primary percutaneous coronary intervention ( PCI ) is more effective than fibrinolytic therapy for ST-segment elevation acute myocardial infarction ( ...

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Relapsing multiple sclerosis: FDA has approved the reintroduction of Tysabri

The FDA ( U.S. Food and Drug Administration ) has approved the reintroduction of Tysabri ( Natalizumab ) as a ...

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Antitumor activity of Panitumumab in metastatic colorectal cancer

Results from two studies suggest that antitumor activity of Panitumumab was independent of tumor EGFr expression levels in patients with ...

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Vorinostat in patients with advanced, refractory cutaneous T-cell lymphoma

A pivotal Phase IIb open-label study evaluated Vorinostat ( Zolinza ) in patients with advanced, refractory cutaneous T-cell lymphoma ( ...

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Chemotherapy-induced anemia: benefits of Aranesp with intravenous Iron

A study suggests that Aranesp ( Darbepoetin alfa ) administered every three weeks with intravenous ( IV ) iron has ...

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Better survival seen for early breast cancer patients switched from Tamoxifen to Exemestane

Hormone sensitive postmenopausal early breast cancer patients who switched to Exemestane ( Aromasin ) after 2 to 3 years of ...

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Advanced breast cancer: Tykerb an alternative to Herceptin

A Phase III study has shown that Lapatinib ( Tykerb ) and Capecitabine ( Xeloda ) versus Capecitabine alone nearly ...

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Evista associated with increased risk of stroke mortality in postmenopausal women at increased risk for cardiovascular disease

Health Canada has informed Health Care Professionals of important new safety information regarding Evista ( Raloxifene ) resulting from the ...

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Advanced HER2-positive breast cancer: Herceptin added to hormonal therapy prolongs progression-free survival

Data from TAnDEM study have shown that the addition of Trastuzumab ( Herceptin ) to the hormonal therapy, Anastrozole ( ...

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EU: Herceptin for early-stage in HER2-positive breast cancer approved

The European Commission has approved Herceptin ( Trastuzumab ) for patients with early-stage HER2-positive breast cancer following surgery and standard ...

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p11 appears to help regulate signaling of the brain messenger chemical serotonin

A protein that seems to be pivotal in lifting depression has been discovered by Paul Greengard. " Mice deficient in this ...

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How one disease may prevent another

The knowledge that one disease may prevent the onset of another is not new. For example, the discovery that cowpox ...

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Treating periodontal disease may reduce the risk of cardiovascular disease

Researchers from Sydney Dental Hospital and Royal North Shore Hospital ( Australia ) and University of Oslo ( Norway ) ...

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Azilect, a new treatment for Parkinson's Disease

The FDA ( U.S. Food and Drug Administration ) has approved Azilect ( Rasagiline ) for the treatment of ...

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Blood test can predict long-term risk of death in patients with shortness of breath

Researchers from Massachusetts General Hospital ( MGH ) have shown that a blood test previously found useful for diagnosing heart ...

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Low-carbohydrate diets appear effective, but may raise cholesterol levels

Data from five previous clinical trials, published in the Archives of Internal Medicine, suggest that both low-fat and low-carbohydrate diets ...

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Tumor size related to lung cancer spread

Smaller tumors in the lungs appear to be less likely to have spread than larger tumors among patients with asymptomatic ...

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Estrogen therapy does not appear to protect postmenopausal women from heart disease

Estrogen therapy does not appear to reduce the risk of heart attack or coronary death in healthy postmenopausal women, although ...

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Pyridostigmine appears to improve standing blood pressure in patients with orthostatic hypotension

Use of a medication called Pyridostigmine alone or in combination with low-dose Midodrine appears to improve standing blood pressure in ...

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Glaucoma patients appear to have increased eye pressure during sleep

Some patients with glaucoma appear to have higher pressure in their eyes during sleep at night than during the day ...

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For men with cardiovascular disease, there is apparently no normal glucose level

A study by a team of researchers at UCLA and Cedars-Sinai Medical Center in Los Angeles suggests that men with ...

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Adalimumab for maintaining clinical remission in patients with Crohn's disease

The results from a study showing patients with moderate to severely active Crohn's disease treated with Adalimumab ( Humira ) ...

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Basic research at the Max Planck Institute of Biochemistry leads to a novel cancer therapy

Axel Ullrich, at the Max Planck Institute of Biochemistry in Martinsried, Germany, already showed at the beginning of the 1990s ...

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Neurodegenerative disease: mechanism that causes cell death

Misfolded and damaged proteins are common to all human neurodegenerative diseases. Clumps of these aggregated proteins destroy neurons within the ...

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