FDA approves Asmanex for once-daily treatment of asthma
The FDA ( Food and Drug Administration ) has approved the use of Asmanex Twisthaler 220 mcg ( Mometasone ...
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Low-dose Aspirin for prevention of stroke in women
A study performed at Harvard Medical School found that low-dose Aspirin may reduce the risk of ischemic stroke in women.
Previous ...
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Depo-subQ Provera 104 ( Medroxyprogesterone ) for endometriosis pain
The FDA ( Food and Drug Administration ) approved Depo-subQ Provera 104 ( Medroxyprogesterone ) for the management of pain ...
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Intracranial stenosis, Aspirin is safer than Warfarin for stroke prevention
A randomized trial showed that Aspirin is safer than Warfarin for stroke prevention in patients with intracranial arterial stenosis.
Intracranial stenosis ...
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Chronic hepatitis B, FDA approves Entecavir
The FDA ( Food and Drug Administration ) approved Baraclude ( Entecavir ) tablets and oral solution for the treatment ...
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Viagra may cause ischemic optic neuropathy
Researchers from the University of Minnesota in Minneapolis, reported seven patients who developed nonarteritic anterior ischemic optic neuropathy ( NAION ...
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Lung cancer, positive preliminary data for ProMune
ProMune is a synthetic agonist for Toll-like receptor 9 ( TLR9 ).
By stimulating TLR9, ProMune acts directly and selectively on ...
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Folate intake associated with hypertension in women
Higher total folate intake is associated with a decreased risk of hypertension, particularly in younger women.
Researchers at Harvard Medical School ...
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Bortezomib approved for second-line multiple myeloma
The U.S. FDA ( Food and Drug Administration ) approved a supplemental New Drug Application ( sNDA ) for Velcade ...
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Abbott, ADHD drug is being discontinued
Abbott’s Cylert ( Pemoline ) is a central nervous system stimulant indicated for the treatment of attention deficit hyperactivity disorder ...
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Osteoporosis, FDA approves once-monthly Ibandronate
The U.S. FDA ( Food and Drug Administration ) approved once- monthly oral Ibandronate ( Boniva ) 150 mg tablets, ...
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Finasteride may prevent prostate cancer
Finasteride ( Proscar ) blocks an enzyme called 5-alpha-reductase, which is necessary to change testosterone to another hormone that causes ...
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Obstructive sleep apnea and risk of sudden death from cardiac causes
The risk of sudden death from cardiac causes is highest between the hours of 6 a.m. and noon and ...
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Coronary heart disease, high-versus low dose Atorvastatin
The Third Report of the National Cholesterol Education Program ( NCEP ) - Adult Treatment Panel and the most recent ...
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Public Citizen petitions FDA to withdraw Abbott’s Cylert
Public Citizen, a U.S. consumer organization, petitioned the U.S. Food and Drug Administration (FDA) to immediately remove Pemoline ...
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Epilepsy drug Valproate during pregnancy may increase the risk of severe birth defects
Valproate ( Valproic Acid ), an epilepsy drug, is indicated as monotherapy and adjunctive therapy in complex partial seizures in ...
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Nesiritide increases the risk of worsening renal function in patients with ADHF
In 2001, Nesiritide ( Natrecor ) has been approved by the FDA for the intravenous treatment of patients with acutely ...
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Avonex associated with cases of severe liver damage
Avonex, Interferon beta-1a, is approved for the treatment of patients with relapsing forms of multiple sclerosis to slow the accumulation ...
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New warning for Xigris, a sepsis drug
Xigris has received FDA approval for increasing survival in high-risk adult patients with severe sepsis.
Xigris ( Drotrecogin alfa, activated ...
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Role of anti-hepatitis C virus treatment in patients with B-cell non-Hodgkin's lymphoma and HCV infection
Hepatitis C virus ( HCV ) plays a role in the development of both hepatocellular carcinoma and B-cell non-Hodgkin's lymphoma ...
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Cholesterol affects tumor survival
Lipid rafts are cholesterol- and sphingolipid-enriched microdomains in cell membranes that regulate phosphorylation cascades originating from membrane-bound proteins.
They are dynamic ...
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Smoking may be a risk factor for progression of multiple sclerosis
An increased risk of multiple sclerosis among smokers has been found in several prospective epidemiological studies.
Investigators from Harvard School of ...
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BNP is a strong prognostic indicator in patients with heart failure
The clinical assessment of heart failure is difficult; it is difficult to determine which patients have heart failure and, once ...
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FDA approves Symlin, new diabetes drug
The FDA ( Food and Drug Administration ) approved Symlin, an injectable drug to control blood sugar for adults ...
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Parecoxib and Valdecoxib, increased cardiovascular events after CABG
A study, led by Nancy A. Nussmeier at the Texas Heart Institute, St. Luke's Episcopal Hospital, in Houston, assessed the ...
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Aliskiren, a novel renin inhibitor in hypertension
Aliskiren ( SPP100 ) is the first in the new class of antihypertensive agents, called renin inhibitors.
Suppression of the renin ...
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FDA approves Temodar as treatment for glioblastoma multiforme
The FDA ( Food and Drug Administration ) has approved a new indication for Temozolomide ( Temodar ), ...
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Vitamin E can increase the risk for heart failure
A study has shown that in patients with vascular disease or diabetes mellitus, long-term vitamin E supplementation does not prevent ...
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Lung cancer, Avastin extends survival
An interim analysis of a Phase III study of Avastin ( Bevacizumab ) in combination with Paclitaxel and Carboplatin ...
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Autoantibody formation in patients with rheumatoid arthritis treated with Infliximab
Long-term use of anti-TNF-alpha agents can lead to the development of autoantibodies.
Infliximab ( Remicade ) is a chimeric human-murine monoclonal ...
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Rasagiline as an adjunct to Levodopa in patients with Parkinson's disease and motor fluctuations
Management of patients with complications of Parkinson's disease remains a challenge for both the clinician and the patient.
These complications ...
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Risk factors for preeclampsia
Preeclampsia, a major cause of maternal and fetal mortality and morbidity, is characterized by development of swelling, elevated blood pressure ...
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Aripiprazole for maintaining efficacy in bipolar I disorder
The U.S. FDA ( Food and Drug Administration ) approved Aripiprazole ( Abilify ) for maintaining efficacy in patients with ...
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Two atopic dermatitis drugs should be used cautiously
The U.S. FDA ( Food and Drug Administration ) advised health care professionals to prescribe Elidel ( Pimecrolimus ) ...
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Rituximab plus short-duration chemotherapy as first-line treatment for follicular non-Hodgkin’s lymphoma
A phase II trial, led by John D. Hainsworth of the Sarah Cannon Cancer Center and Tennessee Oncology, Nashville ...
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Bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma
A phase II study, led by Andre Goy, of the University of Texas M.D. Anderson Cancer Center, Houston, evaluated efficacy ...
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Non-diabetic proteinuric nephropathies, add-on therapy provides no benefit
In chronic nephropathies, ACE inhibitors have renoprotective effect.
REIN-2 Study Group assessed the effect of intensified versus conventional blood-pressure control on ...
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Addition of Clopidogrel to Aspirin and fibrinolytic therapy proves beneficial for myocardial infarction
Patients whose occluded arteries were treated with standard fibrinolytic regimen , including Aspirin, following acute myocardial infarction with ST-segment elevation ...
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Celecoxib inhibits prostate cancer growth
Selective cyclooxygenase-2 ( COX-2 ) inhibitors may suppress carcinogenesis by both COX-2-dependent and COX-2-independent mechanisms.
Researchers at the Weill Medical College ...
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ADRAC : bisphosphonates and osteonecrosis of the jaw
Bisphosphonates are drugs commonly used to prevent and treat osteoporosis in post-menopausal women.
They are widely used in the management ...
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APC study, cardiovascular risk associated with Celecoxib
Adenoma Prevention with Celecoxib ( APC ) study investigators reviewed all potentially serious cardiovascular events among 2035 patients with a ...
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Efficacy of Lenalidomide in relapsed or refractory multiple myeloma
The IDMC ( Independent Data Monitoring Committee ) found a statistically significant improvement in time to disease progression in patients ...
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WHO: public health concern on acrylamide in food
In 2002, Swedish studies showed for the first time the unintentional formation of relatively high levels of acrylamide during the ...
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Genetic variants in UBQLN1 increase the risk of Alzheimer’s disease
Researchers from the MassGeneral Institute for Neurodegenerative Disorders ( MIND ) in Charlestown have identified a gene variant that may ...
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Diabetes increases liver cancer risk
A study, carried out by investigators at Houston Veterans Affairs Medical Center, examined the association between diabetes and increased ...
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Alzheimer’s disease could be a neuroendocrine disorder
The accumulating evidence that reduced glucose utilization and deficient energy metabolism occur early in the course of disease, suggests a ...
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FDA has approved Pegasys and Copegus for the treatment of chronic hepatitis C in HIV patients
FDA ( Food and Drug Administration ) has approved Pegasys ( Peginterferon alfa-2a ) and Copegus ( Ribavirin ) for ...
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Thalidomide attenuates weight loss and wasting in pancreatic cancer
Thalidomide was first marketed in Europe in the late 1950's. It was used as a sleeping pill and to ...
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European Union, Pegasys approved for the treatment of chronic hepatitis B
European Commission has approved Pegasys ( Peginterferon alfa-2a ) for the treatment of chronic hepatitis B.
The approval is granted ...
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Low-dose Aspirin prevents strokes in women
The Women's Health Study ( WHS ) is a randomized, double-blind, placebo-controlled trial evaluating the balance of benefits and risks ...
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Peginterferon alfa-2a plus Ribavirin for chronic hepatitis C virus infection in HIV-infected patients
The final statement from the 1st European Consensus Conference on the Treatment of Chronic Hepatitis B and C in HIV ...
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Drug-eluting stent: Cypher and Taxus, comparable efficacy in preventing in-segment binary restenosis
The REALITY Trial is a prospective, randomized study involving 1,386 patients at 90 hospitals centers in Europe, Latin America and ...
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Recombinant activated factor VII in acute intracerebral haemorrhage
The New England Journal of Medicine ( NEJM ) reports positive results from the clinical trial of recombinant activated factor ...
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FDA has approved Candesartan Cilexetil for the treatment of heart failure
AstraZeneca announced that the US Food and Drug Administration (FDA) has approved its angiotensin receptor blocker (ARB) Candesartan Cilexetil ( ...
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Treatment of systolic hypertension in older patients with SBP of at least 160 mm Hg is supported by strong evidence
A review of the medical literature suggests that older persons with systolic hypertension (and systolic blood pressure of at least ...
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A to Z Trial , Z phase : Simvastatin did not achieve the prespecified end point
The Aggrastat to Zocor study, or A to Z study, phase Z has assessed whether early intensive Simvastatin treatment ...
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ACTION trial : addition of Nifedipine GITS to conventional treatment of angina pectoris has no effect on major cardiovascular event-free survival
Calcium antagonists such as Nifedipine are used to relieve the symptoms of angina, but there have been doubts about their ...
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Alzheimer’s drugs, NICE proposes to withdraw from NHS
The drugs Donepezil ( Aricept ), Rivastigmine ( Exelon ), Galantamine ( Remynil ), and Memantine ( Ebixa ) should ...
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Therapeutic vaccine shows promise in men with prostate cancer
Telomerase reverse transcriptase ( hTERT ) represents an attractive target for cancer immunotherapy because hTERT is reactivated in most human ...
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Prostate cancer, vitamin E could cut the risk
The ATBC ( Alpha-Tocopherol, Beta-Carotene Cancer Prevention ) study investigated risk factors and prevention of major chronic diseases, such as ...
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Dietary fiber intake reduces blood pressure in patients with hypertension
People who ate 7.2 to 18.9 grams of fiber a day experienced a reduction in both systolic and diastolic blood ...
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FDA: Crestor, favorable risk/benefit ratio
The Food and Drug Administration ( FDA ) issued a public health advisory, a patient information sheet and a corresponding ...
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Use of Cannabis may lead to psychotic symptoms
New research appearing in the journal Addiction supports the growing evidence that Cannabis can seriously damage mental health.
Cannabis is thought ...
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Folate and vitamin B12 can reduce the risk of hip fracture in elderly patients following a stroke
Hyperhomocysteinemia is a risk factor for both ischemic stroke and osteoporotic fractures in elderly men and women.
Folate and vitamin ...
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Multiple Sclerosis, Tysabri withdrawn from market
The Food and Drug Administration ( FDA ) issued a public health advisory to inform patients and health care providers ...
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Guidelines on use of Antiretroviral Drugs to prevent HIV infection after sexual, drug use, and accidental exposure
CDC ( Centers for Disease Control and Prevention ) has announced new guidelines for the use of antiretroviral drugs to ...
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Linezolid and neuropathy
Linezolid ( Zyvoxam ), a synthetic antibacterial agent in a new class of antibiotics, the oxazolidinones, has been marketed in ...
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Reports of lymphoma and skin cancer in patients treated with Elidel cream
FDA is investigating postmarketing reports of lymphoma and skin cancer in children and adults treated with Elidel ( Pimecrolimus ), ...
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EMEA, regulatory actions for the COX-2 inhibitor
The European Medicines Agency has announced a number of regulatory actions for the COX-2 inhibitor class of medicines following discussions ...
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New Warning on Depo-Provera Contraceptive Injection
The FDA announced that a new black-box warning has been added to the labeling for Depo-Provera Contraceptive Injection. The ...
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NCI has stopped a clinical trial of the Cox-2 Inhibitor Celebrex
The FDA released the following statement on the halting of a clinical trial of the Cox-2 inhibitor Celebrex ( celecoxib ...
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Bextra, boxed warning concerning severe skin reactions and warning regarding cardiovascular risk
FDA announced important new information on side effects associated with the use of Bextra, a COX-2 selective non-steroidal anti-inflammatory ...
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Warning on lymphoma risk with TNF blockers
The manufacturers of the drugs Humira ( adalibumab ), Remicade ( infliximab ) and Enbrel ( etanercept ) have added ...
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Treatment for patients with the metabolic syndrome
A study presented at the 40th Annual Meeting of the European Association for the Study of Diabetes ( EASD ), ...
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Vioxx, increased risk of heart attack and stroke
Merck is withdrawing Vioxx ( Rofecoxib ) from the market after the data safety monitoring board overseeing a long-term study ...
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Potential adverse effects of SSRIs and other anti-depressants on newborns
Newborns may be adversely affected when pregnant women take Selective Serotonin Re-uptake Inhibitors ( SSRIs ) and other newer anti-depressants ...
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Valdecoxib, severe cutaneous reactions
Valdecoxib ( Bextra ), a selective inhibitor of cyclo-oxygenase 2 ( COX-2 ), is indicated for the treatment of acute ...
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