Prenatal cocaine exposure causes injury on heart

A research by Lubo Zhang and his colleagues from Loma Linda University- School of Medicine in California presents the finding ...

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Fracture prevention with high dose vitamin D

A high dose of oral vitamin D supplementation may reduce the risk of hip and nonvertebral fracture in the enderly. The ...

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FLAP inhibitor reduces markers linked to cardiac risk

A study suggests that use of a investigational drug, DG-031, that inhibits a specific protein in patients with genetic variants ...

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Cystic fibrosis DNA test

Tag-It Cystic Fibrosis ( CF ) Kit is the first multiplexed human disease genotyping test to be cleared by the ...

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Heart-rate during and after exercise is a predictor of sudden death

The results of a study showed that the heart-rate profile during exercise and recovery is a predictor of sudden death. ...

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Cystic fibrosis, FDA approves first DNA-based blood test

FDA ( Food and Drug Administration ) has approved the first DNA-based blood test, Tag-It Cystic Fibrosis Kit, to help ...

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Radical prostatectomy improves survival in younger men

A study suggests that men under 65 who choose prostate surgery have higher long-term survival rates than those who ...

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Season of birth influences age of menopause

An Italian study of 2,822 post-menopausal women showed that the earliest age of menopause was found in women born in ...

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Statin may slow Alzheimer’s disease

Treatment with Atorvastatin ( Lipitor ), a cholesterol-lowering drug, may be of some clinical benefit on measures of cognitive and ...

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Commonly prescribed drugs linked to sudden death

Some commonly prescribed drugs may interfere with the electrical activity controlling the heartbeat, increasing the risk of sudden cardiac ...

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Diabetes, low-fat dairy products may lower the risk

Diet and lifestyle modifications can substantially reduce the risk of type 2 diabetes. A study showed that eating low-fat dairy products ...

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Food allergen sensitivity may be a marker for increased asthma severity

Asthma continues to be an increasing cause of morbidity in the pediatric population, and studies have shown an association between ...

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Aspirin may speed up recovery from CABG surgery

Patients who are to undergo CABG ( coronary artery bypass grafting ) routinely stop low-dose Aspirin therapy 7 to 10 ...

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High risk of depression in subjects with 5-HTTLPR polymorphism

Researchers at the National Institute of Mental Health ( NIMH ), a part of National Institute of Health ( NIH ...

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Alzheimer’s vaccine, hopeful results from interrupted trial

In January 2002 Elan Corporation and Wyeth-Ayerst Laboratories suspended their Phase IIA clinical trial of AN1792, also known as the ...

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Antibody-based therapy shows durable responses in metastatic melanoma

Seven of 56 patients with metastatic melanoma showed durability of complete or partial responses ranging from four months to the ...

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Long-term risk for untreated low-grade ductal carcinoma in situ

Women who have ductal carcinoma in situ ( DCIS ) are very likely to develop invasive breast cancer if left ...

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Acute coronary syndrome, Morphine linked to higher mortality

An analysis by researchers from the Duke Clinical Research Institute has shown that patients hospitalized for non–ST-segment elevation acute coronary ...

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Identified loci contributing to metabolic phenotypes of hypertension

Canadian and US researchers at the Medical College of Wisconsin studied 120 families in the isolated Saguenay-Lac St. Jean region ...

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Chronic lymphocytic leucemia, MRD-negative remission with Alemtuzumab improves survival

The 84 percent of patients who had no detectable traces of chronic lymphocytic leukemia ( CLL ) after receiving Alemtuzumab ...

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Doubts on acupuncture for treatment of migraine

Acupuncture was no more effective than sham acupuncture in reducing migraine headaches. Acupuncture is widely used to prevent migraine attacks, ...

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Brain tumor, new molecular targets and treatment approaches

Researchers at Wake Forest University Baptist Medical Center found promising new molecular targets and treatment approaches for glioblastoma multiforme, the ...

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Mosaic mouse technique, a new tool to study diseases and genetics

Researchers from Stanford University described a streamlined method for creating a " genetic mosaic mouse ", a rodent whose body ...

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Immune and protein alterations in children with autism

Scientists from the UC Davis M.I.N.D. ( Medical Investigation of Neurodevelopmental Disorders ) Institute presented, at the 4th International ...

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FDA approves first drug for Restless Legs Syndrome

FDA ( Food and Drug Administration ) has approved Ropinirole ( Requip ), an orally administered anti-Parkinsonian drug, for ...

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Prescribing restrictions for all COX-2 inhibitors

After evaluation of the available data, and consideration of submissions from patients and health professionals, the Medicines Adverse Reactions Committee ...

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Eczema, Elidel and Protopic linked to cancer risk

Health Canada is advising people who use Elidel ( Pimecrolimus ) cream and Protopic ( Tacrolimus ) ointment about safety ...

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Catalase enzyme prolongs mouse lifespan

A research, led by scientists from University of Washington in Seattle, has found that mice genetically engineered to produce high ...

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Synvisc: reported incidents of joint inflammation and pain

Hylan G-F 20 ( Synvisc ) is an elastoviscous fluid containing hylan polymers, which are derivatives of hyaluronan ( ...

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Betaseron, hepatotoxicity

Berlex, according to FDA ( Food and Drug Administration ), informed “ HealthCare Professional “ about the safety profile ...

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Non–small-cell lung cancer, high EGFR gene copy number may be a predictor for Gefitinib efficacy

High copy number of the epidermal growth factor receptor ( EGFR ) may be an effective predictor of Gefitinib ( ...

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Atrial fibrillation, Amiodarone more efficacy than Sotalol for maintaining sinus rhythm

Amiodarone ( Cordarone ) is more efficacy than Sotalol ( Betapace ) for maintaining sinus rhythm, but both drugs have ...

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Chronic hepatitis C, Peginterferon alfa-2b plus Ribavirin in children and adolescents

More than half of 61 children and adolescents infected with chronic hepatitis C achieved a sustained viral response after treatment ...

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Acetaminophen, associated with an increased risk of asthma and COPD

Researchers found that increased use of the pain medication Acetaminophen, known as Paracetamol in Europe, was associated with a greater ...

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Psoriatic arthritis, sustained benefits of Infliximab therapy

In the IMPACT ( Infliximab Multinational Psoriatic Arthritis Controlled Trial ) study, 104 patients with active psoriatic arthritis who had ...

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Clopidogrel and Aspirin for reduction of emboli in symptomatic carotid stenosis

Symptomatic carotid stenosis patients are at high risk of early recurrent stroke. The CARESS ( Clopidogrel and Aspirin for Reduction of ...

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Erlotinib in the treatment of advanced or metastatic pancreatic cancer

Erlotinib ( Tarceva ) is the first drug and the only EGFR-targeted treatment shown to prolong survival in a phase ...

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Reduction of leiomyoma volume with the GnRH antagonist Ganirelix

Dutch investigators assessed maximal volume reduction of leiomyomas and uterus and the duration of treatment required to reach these reductions ...

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ACAT2, a new target for atherosclerosis

Research in animals suggests that an enzyme called ACAT2 may play a major role in the atherosclerosis, and that drugs ...

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Tibolone and estrogen-only HRT up endometrial cancer risk

Estrogens and Tibolone ( Livial ) increase the risk of endometrial cancer. Many postmenopausal women, who have not had a ...

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Diabetes, FDA approves Byetta ( Exenatide )

FDA ( Food and Drug Administration ) has approved Exenatide ( Byetta ), also known as synthetic exendin-4, injection as ...

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Multiple myeloma, EU approves Velcade as a second-line treatment

The European Commission has approved the use of Bortezomib ( Velcade ) for Injection as a second-line treatment in patients ...

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Epilepsy: Oxcarbazepine, serious dermatological reactions and multi-organ hypersensitivity

Important changes have been made regarding warnings and precautions sections of the prescribing information for Oxcarbazepine ( Trileptal ). Trileptal ...

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Vitamin D, calcium supplements don’t reduce fracture risk

A study found no evidence that Calcium and Vitamin D ( Cholecalciferol ) supplements reduce the risk of fractures of ...

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Cholesterol proteins linked to cardiovascular risk in dialysis patients

Both low molecular weight apo(a) size and high lipoprotein(a) levels predict atherosclerotic cardiovascular disease risk in dialysis patients. Led by J. ...

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Exenatide reduces HbA1c in patients poorly controlled on Metformin

Exenatide reduced HbA1c with no weight gain and no increased incidence of hypoglycemia in patients with type 2 diabetes failing ...

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Imiquimod cream for the treatment of actinic keratosis

The 5% Imiquimod cream ( Aldara ) dosed 3 times weekly for 16 weeks is safe and effective for the ...

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EMEA recommends strong warnings for antidepressants in paediatric use

EMEA ( European Medicines Agency ) has completed its review of two classes of antidepressants and concluded that they should ...

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Herceptin improves survival in early breast cancer

Two Phase III trials of Herceptin ( Trastuzumab), a monoclonal antibody, were stopped early after a preliminary joint interim analysis ...

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Clinical applications of induced metabolic hibernation

Researchers at Fred Hutchinson Cancer Research Center ( FHCRC ) in Seattle have, for the first time, induced a state ...

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West Nile, developed a monoclonal antibody with therapeutic potential

Researchers from Washington University – School of Medicine at St. Louis developed a monoclonal antibody that mimics one produced by ...

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Alzheimer, NGF gene therapy slows cognitive decline

Nerve growth factor ( NGF ) gene therapy may slow the rate of cognitive decline in patients with Alzheimer’s disease ...

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Sleep disturbances linked to metabolic syndrome

Mice with a mutation in a gene called "Clock," which helps drive circadian rhythm, ate significantly more and gained more ...

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DNA hypomethylation can be reversed by intake of Folic Acid

In an article that appeared in Gastroenterology ( 2003 ) researchers at King’s College London demonstrated that low folate status ...

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Psoriasis: BG-12, a new oral treatment

A Phase III study designed to evaluate the efficacy and safety of BG-12, an oral fumarate, in the treatment of ...

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Diabetes, Metformin may reduce risk of cancer

Patients with type 2 diabetes who take Metformin seem to be at lower risk of cancer than those not treated ...

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Cannabis extract for neuropathic pain in multiple sclerosis

Sativex is a cannabis based medicine containing Tetranabinex and Nabidiolex extracts of chemically and genetically characterised Cannabis sativa L. plants. ...

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Exposure to infections in early life protects against childhood leukemia

Exposure to infections in the first months and years of life is known to be necessary for normal development of ...

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Multiple sclerosis, cannabis spray for neuropathic pain

Health Canada has issued a conditional marketing authorisation under the Notice of Compliance with Conditions ( NOC/c ) policy for ...

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Long-term efficacy of PUVA therapy for mycosis fungoides

Psoralen plus UV-A ( PUVA ) monotherapy is an effective therapy for mycosis fungoides. Researchers from Northwestern University in Chicago evaluated ...

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Chlamydia vaccine as alternative to antibiotics for atherosclerosis

Since Chlamydia pneumoniae is believed to be involved in the pathogenesis of coronary artery disease, ACES study investigated whether antibiotic ...

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FDA recommends caution against use of Reminyl for MCI

After the deaths of 13 patients taking Reminyl ( Galantamine ) during two investigational studies, drug's prescribing information has ...

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Antibiotics fail to prevent coronary events

New study has showed that antibiotic treatment does not reduce risk of secondary cardiac events. . Taking antibiotics weekly for one ...

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Tuberculosis in the United States, 2004

More than one-third of the global population is infected with the tuberculosis (TB ) bacterium, and TB disease remains one ...

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Statins may reduce the risk of advanced prostate cancer

Use of statins may reduce the risk of advanced prostate cancer, according to research that followed 34,428 U.S. men for ...

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Sézary syndrome, Bexarotene induces apoptosis in malignant T cells and inhibits interleukin-4 production

Bexarotene, a selective retinoid X receptor ( RXR ) modulator, induces apoptosis of malignant T cells isolated from patients with ...

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Depression and pessimism increase dementia risk

Subjects who do not have psychiatric disorders but score very high on a personality test pessimism or depression scale have ...

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FDA approves Hyzaar for prevention of stroke in patients with hypertension and LVH

The FDA ( Food and Drug Administration ) has approved another new indication for Hyzaar, fixed-dose combination antihypertensive drug ( ...

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Waist circumference to predict insulin resistance

Waist circumference is a strong indicator of the risk of insulin resistance, an early stage in the development of diabetes ...

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Rimonabant reduces bodyweight and cardiovascular risk factors in overweight patients

Rimonabant 20 mg, combined with a hypocaloric diet over 1 year, promoted significant decrease of bodyweight and waist circumference, and ...

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Increased risk for Parkinson’s Disease and parkinsonism after ovary removal

Mayo Clinic researchers found that surgical removal of both ovaries doubles a woman’s risk of developing Parkinson’s disease and parkinsonism ...

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Avastin, significant benefit in first-line metastatic breast cancer

An interim analysis of a Phase III study of Bevacizumab ( Avastin ) plus Paclitaxel chemotherapy in first-line metastatic breast ...

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Celebrex: cardiovascular risk similar to Vioxx - IMMP study

Patients taking the arthritis drug Celecoxib ( Celebrex ) have a similar risk of heart attacks and stroke as those ...

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Steroids as needed for mild persistent asthma

It may be possible to treat mild persistent asthma with short, intermittent courses of inhaled or oral corticosteroids taken when ...

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Ibuprofen may lower risk of Parkinson's disease

Ibuprofen, an anti-inflammatory drug, may help to prevent or delay the onset of Parkinson's disease. The purpose of the study was ...

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Progression from mild cognitive impairment to Alzheimer’s disease: little benefit from Donepezil

In a study of people with mild cognitive impairment ( MCI ), those who took the drug Donepezil were ...

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FDA Panel votes against Inamed's silicone breast implants

FDA's General and Plastic Surgery Devices Advisory Panel recommended that the FDA not approve Inamed's silicone-filled breast implants for use ...

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Statins help improve recovery after an ischemic stroke

The use of cholesterol-lowering drugs, called statins, before or after a stroke helps improve patient recovery after an ischemic ...

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No link between use of cell phone and risk for brain tumors

A study, supported by the European Commission Fifth Framework Program - Quality of life and management of living resources, ...

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Erythropoietin may reduce the risk for blood transfusions and improve hematologic response in cancer patients

Erythropoietin treatment for anemia may reduce the risk for blood transfusions and improve hematologic response in cancer patients, but evidence ...

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Products derived from bees: serious adverse reactions

Substances derived from bees include bee pollen, royal jelly and propolis. Bee pollen can come from a variety of plants and ...

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Fish and soil oil may protect against heart attacks

A study, led by Fernando Holguin, Emory University School of Medicine, Atlanta, found that taking daily supplements of fish or ...

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Rituximab improves symptoms in RA patients non-responders to anti-TNF therapies

A Phase III clinical study of Rituximab ( Rituxan ) met its primary endpoint of a greater proportion of Rituximab-treated ...

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FDA warns on unapproved use of atypical antipsychotic drugs

The FDA ( Food and Drug Administration ) issued a public health advisory to alert health care providers, patients, ...

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Blood test can diagnose heart failure in emergency patients

A new blood test that measures a particular marker of cardiac distress can markedly improve the ability to diagnose or ...

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Pfizer, suspended sales of Bextra in Europe

Following discussions with the European Medicines Agency ( EMEA ), Pfizer has agreed to the suspension of use of anti-inflammatory ...

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Ugandan AIDS study, no evidence of serious violations

In the fall of 2004, the NIH ( National Institute of Health ) requested that the Institute of Medicine ( ...

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Staph infection spreads into community

Methicillin-resistant Staphylococcus aureus ( MRSA ) infections occur most frequently among persons in hospitals and healthcare facilities ( such as ...

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Alcohol dependence, long-acting Naltrexone may be of benefit

Long-acting injections of the drug Naltrexone, combined with psychotherapy, significantly reduced heavy drinking in patients being treated for alcohol dependence. Oral ...

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FDA, changes to the class of non-steroidal anti-inflammatory drugs

The FDA ( Food and Drug Administration ) announced a series of important changes pertaining to the marketing of the ...

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Hypertension, diuretics work better than newer therapies

Thiazide-type diuretics remain the drugs of choice for initial therapy of high blood pressure in both black and non-black patients. ...

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Mediterranean diet increases survival among elderly

Mediterranean diet may be beneficial to health, and it seems to prolong the life. The Mediterranean diet is characterised by a ...

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Cervical cancer vaccine seems promising

An investigational vaccine against HPV ( Gardasil ) significantly reduced the combined incidence of HPV 6, 11, 16, or 18 ...

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HRT, high-dose progestin may be associated with breast cancer recurrence

In 1997, two randomized trials, the HABITS ( Hormonal Replacement Therapy-Is It Safe ? ) trial and the Stockholm trial, ...

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Vitamin E supplements may speed up development of cancer

Alpha-tocopherol ( vitamin E ) supplementation produced unexpected adverse effects on the occurrence of second primary cancers and on cancer-free ...

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Sexual behavior, teens believe oral sex is safer

Teens believe that oral sex is less risky to their health and emotions than vaginal sex, more prevalent among teens ...

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Sildenafil in hypertensive pregnancy

A study evaluated the effect of Sildenafil ( Viagra ) in hypertensive pregnancy. Results of this experimental study seem to indicate ...

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Cognitive therapy is as effective as antidepressants

Cognitive therapy to treat moderate to severe depression is just as effective as antidepressants, according to a study published in ...

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Role of supplements in preventing infections in elderly people

The evidence for the effectiveness of the routine use of multivitamins in elderly people to reduce infections is weak and ...

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Rheumatoid arthritis, TNF-alpha blockers may cause skin diseases

A prospective cohort study found that Tumour Necrosis Factor alpha ( TNF-alpha ) blocking agents, trigger skin conditions in 25% ...

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