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Neutrophils in lung produce histamine seen in allergies

Researchers have discovered that histamine, the inflammatory compound released during allergic reactions that causes runny nose, watery eyes, and wheezing, ...
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TACE, a new target for the treatment of breast cancer

Researchers have demonstrated that inhibiting the activity of the protease enzyme known as TACE can deprive tumor cells of a ...
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Genome of parasite responsible for trichomoniasis sequenced

Researchers have decoded the genetic makeup of the parasite that causes trichomoniasis, one of the most common sexually transmitted infections ...
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Role for proteomics in identifying hematologic malignancies

Researchers have identified a set of biomarkers that could help clinicians identify a group of hematologic malignancies known as myelodysplastic ...
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CHARISMA trial: lack of evidence of a Clopidogrel-statin interaction

There are conflicting data regarding whether statins predominantly metabolized by CYP3A4 reduce the metabolism of Clopidogrel ( Plavix ) to ...
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CHARISMA trial: an excess of mortality with dual-antiplatelet therapy in the primary prevention of atherothrombotic events

Results from the CHARISMA ( Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance ) trial showed an ...
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FDA permits restricted use of Zelnorm

The FDA ( Food and Drug Administration ) announced that it is permitting the restricted use of Zelnorm ( Tegaserod ...
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The risk of anaphylaxis following administration of Xolair

The full prescribing information for Xolair ( Omalizumab ) includes a new boxed WARNING, updated Warnings, Precautions, and Adverse ...
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European Union: Mircera for treatment of anaemia related to chronic kidney disease approved

Roche announced that the European Commission has approved Mircera to treat anaemia associated with chronic kidney disease. The Commission’s decision ...
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Risk alleles for multiple sclerosis identified

A large-scale genomic study has uncovered new genetic variations associated with multiple sclerosis, findings that suggest a possible link between ...
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iv Bisphosphonates and osteonecrosis of the jaw: elevated risk for patients with underlying malignant condition

Researches at Elkhart General Hospital, in United States, have assessed the prevalence of osteonecrosis of the jaw in patients receiving ...
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Rosiglitazone associated with parotid gland enlargement

The thiazolidinedione Rosiglitazone ( Avandia ) is an insulin sensitizer that is indicated for use either as monotherapy or in ...
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Aripiprazole may cause neuroleptic malignant syndrome

ADRAC ( Adverse Drug Reactions Advisory Committee ) has previously noted that the two oldest of the atypical antipsychotics, Clozapine ...
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Parkinson's disease: medical management of Levodopa-associated motor complications

Levodopa is standard, and often initial, therapy for patients with Parkinson's disease; however, with continued treatment and as the disease ...
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EMEA recommends withdrawal of medicinal products containing Veralipride

The EMEA ( European Medicines Agency ) has recommended the withdrawal of the marketing authorisation for medicinal products containing Veralipride. ...
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Increased incidence of fractures in female patients who received long-term treatment with Avandia for type 2 diabetes mellitus

GlaxoSmithKline ( GSK ) has informed HealthCare Professionals of recent safety data concerning Rosiglitazone-containing products, i.e., Avandia ( Rosiglitazone maleate ...
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The benefit-risk ratio of Rosiglitazone therapy is not defined

Diabetes is a strong, independent risk factor for cardiovascular disease, a problem which accounts for approximately 70% of all mortality ...
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Review of data indicates that Phenylephrine requires further study to demonstrate efficacy and safety

A study has assessed the effectiveness of Phenylephrine, the active ingredient in products such as Actifed, Sudafed PE, and Tylenol ...
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Potentially life threatening side effects combining Aliskiren with Valsartan

Combining Aliskiren ( Rasilez / Tekturna ) with Valsartan ( Diovan / Tareg ) at maximum recommended doses provides significantly ...
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EMEA recommends Acomplia must not be used in patients on antidepressants or with major depression

The EMEA ( European Medicines Agency ) has recommended contraindicating Acomplia ( Rimonabant ), in patients with ongoing major depression ...
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Frontotemporal dementia: a new gene mutation identified

Researchers have identified a new gene mutation linked to frontotemporal dementia, according to a study published in the Neurology. Frontotemporal dementia, ...
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ERF, a new target for Duchenne muscular dystrophy drug therapy

Researchers at the University of Pennsylvania School of Medicine report how the gene for utrophin, which codes for a protein ...
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Y2R inhibitor could reduce abdominal obesity

Researchers at Georgetown University Medical Center have been able to use simple, non-toxic chemical injections to add and remove fat ...
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Mirtazapine and blood dyscrasias

Mirtazapine ( Remeron ), is an analogue of Mianserin and, like Mianserin, has been associated with reports of neutropenia and ...
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Clozapine and myocarditis

Clozapine ( Clozaril ), marketed in Australia since 1993, is an effective antipsychotic for the management of treatment-resistant schizophrenia. All ...
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Saxagliptin added to Metformin improves glycemic control in patients with type 2 diabetes compared to Metformin alone

Phase III data demonstrated that Saxagliptin, an inhibitor of dipeptidyl-peptidase-4 ( DPP-4 ), in combination with Metformin, exhibited a statistically ...
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FDA has approved Lyrica for treatment of fibromyalgia

The FDA ( Food and Drug Administration ) has approved Lyrica ( Pregabalin ), the first drug to treat fibromyalgia, ...
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Nexavar significantly extends overall survival in hepatocellular carcinoma patients

Sorafenib ( Nexavar ) tablets has significantly extended overall survival in patients with hepatocellular carcinoma ( HCC ), or primary ...
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Denosumab reduces the progression of bone erosion

Treatment with Denosumab 60 mg and 180 mg, ( associated with Methotrexate ) reduces the progression of bone erosion. Denosumab is ...
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Alcohol intake associated with decreased risk of developing rheumatoid arthritis

New data suggests that alcohol may protect against rheumatoid arthritis, with three units a week exhibiting protective effects and ten ...
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IKBKE gene linked to breast cancer

Using a novel three-part screening process, researchers at Dana-Farber Cancer Institute have identified a gene that is made inappropriately in ...
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Chronic iron overload: Exjade may cause acute renal failure and cytopenias

Novartis has informed HealthCare Provider about the December 2006 changes made to the WARNINGS and ADVERSE REACTIONS sections of the ...
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B-cell depletion therapy for patients with refractory systemic lupus erythematosus

The 36% of patients with refractory systemic lupus erythematosus ( SLE or lupus ) remain stable after undergoing B-cell depletion ...
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Belimumab improves symptoms in 46 percent of systemic lupus erythematosus patients

Treatment with Belimumab resulted in a sustained improvement of systemic lupus erythematosus ( SLE or lupus ) disease activity in ...
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Letrozole is active in ER-positive ovarian cancer

Researchers by University of Edimburgh have evaluated the efficacy of the aromatase inhibitor Letrozole ( Femara ) in preselected estrogen ...
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FDA has approved Letairis for treatment of pulmonary arterial hypertension

The FDA ( Food and Drug Administration ) has approved Letairis ( Ambrisentan ) for the treatment of pulmonary arterial ...
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Lapatinib in brain metastases associated with breast cancer

One-third of women with HER2-positive metastatic breast cancer currently develop brain metastases. Once the disease advances to this stage, overall ...
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Lapatinib in combination with Paclitaxel as first-line treatment for patients with metastatic or relapsed advanced breast cancer

Paclitaxel ( Taxol ) is one of the most commonly used chemotherapies in breast cancer. Therefore, the evaluation of Lapatinib ...
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MAGE-A3 ASCI: clinical activity of a novel cancer immunotherapeutic in patients with non-small cell lung cancer

Final results of a Phase II clinical trial of MAGE-A3 Antigen-Specific Cancer Immunotherapeutic ( ASCI ) in MAGE-A3 positive patients ...
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Advanced renal cell carcinoma: Temsirolimus improves overall survival

The results of a phase III, randomized clinical study involving patients with advanced renal cell carcinoma and poor prognostic features ...
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Losartan treats muscular dystrophy in mice

Researchers at Johns Hopkins have shown that Losartan ( Cozaar ), a drug commonly used to lower blood pressure, reverses ...
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Acetylsalicylic acid saves lives of cancer patients suffering myocardial infarction

Many cancer patients who have heart attacks often are not treated with life saving Acetylsalicylic acid ( Aspirin ) given ...
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SORL1, a new gene for late-onset Alzheimer's disease

A team of researchers, led by Columbia University Medical Center, Boston University School of Medicine and the University of Toronto, ...
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Telomere length may predict risk of coronary heart disease in middle-aged men

Men with short telomeres, repetitive strips of DNA that cap the ends of chromosomes, may have a higher risk of ...
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FDA: safety information on diabetes drug Rosiglitazone

The FDA ( Food and Drug Administration ) is aware of a potential safety issue related to Rosiglitazone ( Avandia ...
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FDA has approved Lybrel, a contraceptive for continuous use

The FDA ( Food and Drug Administration ) has approved Lybrel, the first continuous use drug product for prevention of ...
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Avandia linked to risk of myocardial infarction and heart-related deaths

The FDA ( Food and Drug Administration ) is aware of a potential safety issue related to Avandia ( Rosiglitazone ...
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Pharmacogenetics of antileukemic drug toxicity

Researchers at St. Jude Children's Research Hospital have discovered inherited variations in certain genes that make children with acute lymphoblastic ...
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Primary gastrointestinal stromal tumor: Imatinib decreases cancer recurrence

Preliminary results from a large, randomized, placebo-controlled clinical trial for patients with primary gastrointestinal stromal tumor ( GIST ), a ...
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FDA has approved Neupro patch for treatment of early Parkinson's disease

The FDA ( Food and Drug Administration ) has approved Neupro ( Rotigotine transdermal system ), a skin patch designed ...
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New warnings about suicidal thinking, behavior in young adults who take antidepressant medications

The FDA ( Food and Drug Administration ) proposed that makers of all antidepressant medications update the existing black box ...
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Avastin linked to tracheoesophageal fistula

Genentech and FDA ( Food and Drug Administration ) informed HealthCare Providers of important new safety information regarding Avastain ( ...
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EPCA-2 prostate cancer test more accurate than PSA testing

A protein identified at Johns Hopkins, early prostate cancer antigen-2 ( EPCA-2 ), may change the way men are screened ...
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Huntington’s disease onset linked to faulty DNA repair

Huntington’s disease, an inherited neurodegenerative disorder that affects roughly 30,000 Americans, is incurable and fatal. But a new discovery about ...
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CYP1A2 inhibitors may lead to substantial increases in Tizanidine blood concentrations

Acorda Therapeutics anf FDA ( Food and Drug Administration ) have informed that concomitant use of Tizanidine ( Zanaflex ) ...
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Cancer: novel regulation of the common tumor suppressor PTEN

PTEN is one of the most commonly mutated tumor suppressor genes. It is an antagonist for many cellular growth, proliferation ...
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FDA has approved Altabax for topical treatment of impetigo

The FDA ( Food and Drug Administration ) has approved Altabax ( Retapamulin ointment ) for topical treatment of impetigo ...
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Novartis has agreed to stop selling Zelnorm in US

The FDA ( Food and Drug Administration ) has informed patients and health care professionals that the sponsor of Zelnorm ...
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FDA has approved HepaGam B to prevent hepatitis B reinfection in liver transplant patients

The FDA ( Food and Drug Administration ) has announced the approval of HepaGam B for the prevention of hepatitis ...
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Multiple myeloma: low-dose Dexamethasone combined with Lenalidomide prolongs survival compared with high-dose Dexamethasone

Preliminary results from a large, randomized clinical trial for patients with newly diagnosed multiple myeloma, has shown that the use ...
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Humira is effective in psoriasis

Two clinical trials of Humira ( Adalimumab ), REVEAL and CHAMPION, have demonstrated promising results in psoriasis. Psoriasis is a ...
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Baraclude: occurrence of a resistant HIV variant in a patient co-infected with HIV and HBV

The EMEA’s Committee for Medicinal Products for Human Use ( CHMP ) reminds healthcare professionals that Baraclude ( Entecavir ) ...
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EMEA: Enzastaurin granted orphan drug status for treatment of diffuse large B-cell lymphoma

Eli Lilly announced that the European Medicines Agency ( EMEA ) has granted Enzastaurin, an investigational, multi-targeted, oral, cancer agent, ...
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Parkinson's disease: Pergolide withdrawn for serious damage to heart valves

The FDA ( Food and Drug Administration ) announced that manufacturers of Pergolide drug products, which are used to treat ...
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A new PPAR-alpha agonist shows no advantages compared with Fenofibrate

Researchers at Cleveland Clinic have recently completed a pair of studies to determine the safety and efficacy of a new, ...
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Torcetrapib fails to slow progression of coronary disease

Researchers at Cleveland Clinic reported that the drug Torcetrapib, despite raising high density lipoprotein cholesterol ( HDL ) by ...
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METEOR Trial: Rosuvastatin effective at halting early atherosclerosis

A study using ultrasound technology has found that Rosuvastatin ( Crestor ), a cholesterol-lowering drug, is also effective at halting ...
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COURAGE Trial: percutaneous coronary intervention adds no benefit over optimal medical therapy alone

Percutaneous coronary intervention ( PCI ) plus optimal medical therapy does not improve outcomes in patients with coronary artery disease, ...
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ERASE Trial: CSL-11, a drug that mimics HDL, has mixed effect on coronary atherosclerosis

Patients with acute coronary syndromes ( ACS ), such as heart attack and recent-onset chest pain, remain at considerable risk ...
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Pioglitazone, a diabetes drug, shows promise for preventing brain injury from radiation therapy

Researchers at Wake Forest University School of Medicine have reported that in animal studies, a common diabetes drug prevents the ...
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No benefit for liver cancer patients from long-acting Octreotide

A double blind study found that long-acting Octreotide ( Sandostatin LAR Depot ) does not improve outcomes for patients with ...
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FDA has approved Soliris for paroxysmal nocturnal hemoglobinuria

The FDA ( Food and Drug Administration ) has approved Soliris ( Eculizumab ). Soliris is the first therapy approved for ...
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FDA requests label change for all sleep disorder drug products

The FDA ( Food and Drug Administration ) has requested that all manufacturers of sedative-hypnotic drug products, a class of ...
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ECG abnormalities linked with increased risk of cardiovascular events in women

Postmenopausal women without symptoms of cardiovascular problems who have minor or major abnormalities on an electrocardiogram are at increased risk ...
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FDA has approved Tykerb for advanced breast cancer patients

The FDA ( Food and Drug Administration ) has approved Tykerb ( Lapatinib ), a new targeted anti-cancer treatment, to ...
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Increased incidence of fractures in women who received long-term treatment with Pioglitazone

Takeda Pharmaceuticals, in according to FDA ( Food and Drug Administration ) has informed healthcare providers about recent safety data ...
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Tumor-free breast tissue can have precancerous changes

A study using mastectomy tissue has shown that precancerous changes can occur in normal-appearing areas of the breast as distant ...
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Carnosinase 1 gene associated with severe kidney failure in diabetes

Researchers at Wake Forest University Baptist Medical Center and the University of Heidelberg has proven that a gene protects some ...
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Pancreatic cancer surgery five-year survivors 65 and up live nearly as long as anyone

A study has shown that pancreatic cancer patients 65 or older who live at least five years after surgery have ...
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Computed tomography screening may increase rate of lung cancer diagnosis, but not decrease risk of death

Screening current or former smokers with the imaging technique of computed tomography ( CT ) may increase the rate of ...
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FDA has approved Humira for Crohn's disease

The FDA ( Food and Drug Administration ) has approved Humira ( Adalimumab ) to treat adult patients with moderately ...
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ADHD Drugs linked to cardiovascular and psychiatric adverse events

The FDA ( Food and Drug Administration ) directed the manufacturers of all drug products approved for the treatment of ...
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Multple sclerosis: parasite infection may be of benefit

A steady rise in autoimmune diseases such as multiple sclerosis has been noted in recent decades, and environmental factors could ...
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Osteosarcoma: no benefit to increasing dose intensity of chemotherapy

A dose-intensive regimen of the chemotherapy drugs Cisplatin and Doxorubicin offered no clinical benefit over standard doses of the chemotherapy ...
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Recentin, a new angiogenesis inhibitor, can reduce size of glioblastoma

Researchers from the Massachusetts General Hospital ( MGH ) Cancer Center have found that AZD2171 ( Recentin ), a new ...
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Gemcitabine appears to delay cancer recurrence following surgery for pancreatic cancer

Use of the drug Gemcitabine for chemotherapy significantly delays the recurrence of cancer, compared to no chemotherapy, for patients following ...
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Levofloxacin may cause dysglycemia and liver disorders

Levofloxacin ( Levaquin ) is a broad-spectrum fluoroquinolone antibiotic that is indicated for the treatment of certain respiratory tract, skin ...
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Alphanate in the treatment of von Willebrand disease

The FDA ( Food and Drug Administration ) announced the approval of antihemophilic factor / von Willebrand factor complex ( ...
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FDA has restricted use of antibiotic Ketek

The FDA ( Food and Drug Administration ) announced revisions to the labeling for the antibiotic Ketek ( Telithromycin ) ...
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Prevalence of congenital heart disease has increased strikingly in adults

The prevalence of congenital heart disease ( CHD ) has increased strikingly in adults and children in a new population ...
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Genetics and lifestyle interact to increase risk for age-related macular degeneration

The interplay between genetic predisposition and exposure to modifiable risk factors can multiply the risk for age-related macular degeneration. Age-related macular ...
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Higher folate levels linked to reduced risk for Alzheimer's disease

Individuals who take in higher levels of the nutrient folate through both diet and supplements may have a reduced risk ...
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Long-term behavioral and neurological problems associated with prenatal exposure to cocaine

Cocaine use during pregnancy can cause subtle but disabling cognitive impairments -- attention deficits, learning disabilities and emotional problems. A ...
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Milk eliminates cardiovascular health benefits of tea

A research, published in the European Heart Journal, has found that the protective effect that tea has on the cardiovascular ...
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Valganciclovir for chronic fatigue syndrome to be tested

A preliminary study suggests there may be hope in the offing for some sufferers of chronic fatigue syndrome ( CSF ...
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Hypertension, prehypertension in young linked with heart enlargement

Hypertension and prehypertension in adolescents and young adults was associated with a higher risk of having an abnormally enlarged heart. ...
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Genomic alterations in the stroma of head and neck squamous cell carcinoma

Preliminary research has indicated that several specific genetic alterations are associated with the development of smoking-related head and neck skin ...
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NT-proBNP level was associated with a greater risk of cardiovascular events or death

A blood test for patients with coronary heart disease could help predict their risk for subsequent cardiovascular events or death. Risk ...
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Improved adherence to statins and beta-blockers associated with longer survival following myocardial infarction

A research suggests that the pharmacological effects of taking medications such as statins and beta-blockers as prescribed following a heart ...
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Excess weight and adult weight gain increase the risk of dying from prostate cancer

A study found that obesity increases the risk of death from prostate cancer, even though it does not increase the ...
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