Intracranial stent reduces arterial blockage in the short term

A preliminary study funded by the National Institutes of Health ( NIH ) found that a stent designed to open ...

Leggi articolo

Progressive multifocal leukoencephalopathy in CellCept treated patients

In agreement with the EMEA, F.Hoffmann-La Roche informed Health Care Professionals of new safety information regarding CellCept ( Mycophenolate ...

Leggi articolo

Provigil associated with serious rash and psychiatric symptoms

Cephalon informed Healthcare Professionals of the following new warnings and safety information for Provigil ( Modafinil ) regarding serious skin ...

Leggi articolo

Ductal carcinoma in situ: patients overestimate breast cancer risks

Many women diagnosed with ductal carcinoma in situ ( DCIS ) have inaccurate perceptions of their breast cancer risks. DCIS is ...

Leggi articolo

HPV-positive head and neck cancer patients have a better response and survival than HPV-negative patients

Head and neck cancer patients with HPV-positive tumors tend to survive longer and are more responsive to treatment compared with ...

Leggi articolo

Additional changes to Ortho Evra, a birth control patch

The FDA ( Food and Drug Administration ) has approved additional changes to the Ortho Evra Contraceptive Transdermal Patch label ...

Leggi articolo

Six infection-related deaths reported after treatment with MabCampath in patients with B-cell chronic lymphocytic leukemia

Bayer Schering Pharma AG and Genzyme Europe BV have informed Healthcare Professionals on six infection-related deaths, reported from a trial ( ...

Leggi articolo

Tysabri to treat moderate-to-severe Crohn's disease: FDA has approved

The FDA ( Food and Drug Administration ) has approved Tysabri ( Natalizumab ) for the treatment of moderate-to-severe Crohn's ...

Leggi articolo

Alpha-Linolenic acid in treatment for dry eye syndrome

Research conducted by Reza Dana, at the Massachusetts Eye and Ear Infirmary ( MEEI ) Cornea Service, and colleagues at ...

Leggi articolo

Oxcarbazepine does not appear to prevent migraine

Contrary to some reports, the epilepsy drug Oxcarbazepine ( Trileptal ) does not appear to prevent migraine. The nearly five-month study ...

Leggi articolo

Additional trials have shown increased mortality and/or tumor progression with Epogen / Procrit and Aranesp

On November 8, 2007, the Aranesp ( Darbepoetin alpha ) and Epogen / Procrit ( Epoetin alpha ) labeling were ...

Leggi articolo

COPD: is Spiriva associated with increased risk of stroke ?

Boehringer Ingelheim has informed the FDA ( Food and Drug Administration ) that ongoing safety monitoring has identified a possible ...

Leggi articolo

Reversal of hypoglycemia in animal model of glycogen storage disease type Ia

A gene therapy treatment that restores a missing liver enzyme in test animals could provide a cure for a rare ...

Leggi articolo

Neuropsychiatric events associated with Tamiflu

Roche has informed HealthCare Professionals on recent update to the Tamiflu ( Oseltamivir ) package insert. The revisions to the product ...

Leggi articolo

Lupus: blocked signals to immune cells extend their life and contribute to progression of disease

Immune cells that would normally die in healthy people accumulate in bodies of patients who have lupus and contribute to ...

Leggi articolo

Crohn's disease: combined immunosuppression therapy better than conventional treatment

Combined immunosuppression therapy is more effective than conventional treatment using corticosteroids for inducing remission in and management of patients recently ...

Leggi articolo

Avastin: VEGF neutralization can damage brain vessels

New research at Schepens Eye Research Institute may help explain why the anticancer drug Avastin ( Bevacizumab ), which targets ...

Leggi articolo

Immunosuppressants: Mycophenolate mofetil linked to specific birth defect pattern

A new study has documentated malformations seen in an infant born to a kidney transplant recipient who had taken Mycophenolate ...

Leggi articolo

Potential biomarkers for psychosis and cerebrovascular disease in patients with systemic lupus erythematosus

Systemic lupus erythematosus ( SLE ) can affect nearly any part of the body, including the joints, skin, kidneys, heart, ...

Leggi articolo

Biochemical bases of 1918 flu pandemic

MIT ( Massachusetts Institute of Technology ) researchers have explained why two mutations in the H1N1 avian flu virus allowed ...

Leggi articolo

Genetic variation to predict initial response to Warfarin identified

Researchers have identified which variations of a specific gene determine a patient’s initial response to treatment with the anticoagulant drug ...

Leggi articolo

Endeavor, a drug-eluting stent for treatment of narrowed coronary arteries

The FDA ( Food and Drug Administration ) has approved the Endeavor Zotarolimus-eluting coronary stent for use in treating patients ...

Leggi articolo

WHI follow up study: risks of long-term combination hormone therapy outweigh benefits for postmenopausal women

New results from the Women's Health Initiative ( WHI ) have confirmed that the health risks of long-term use of ...

Leggi articolo

Oral Terbinafine can be associated with rare but serious and life-threatening toxicities

Oral Terbinafine ( Lamisil ) is approved for the treatment of fungal infections of the nails and skin that are ...

Leggi articolo

Tysabri may cause liver injury

Biogen ldec and Elan have informed HealthCare Profesionals of new safety information regarding Tysabri ( Natalizumab ). The full Prescribing Information ...

Leggi articolo

Arcalyst is first treatment for cryopyrin-associated periodic syndromes

The FDA ( Food and Drug Administration ) has approved a drug to help ease the suffering faced by those ...

Leggi articolo

Gastroesophageal reflux disease: FDA has approved Nexium for use in children ages 1-11 years

The FDA ( Food and Drug Administration ) has approved Nexium ( Esomeprazole ) for short-term use in children ages ...

Leggi articolo

Relapsing-remitting multiple sclerosis: Rituximab shows promise

A drug therapy currently used to treat non-Hodgkin’s lymphoma and rheumatoid arthritis had a significant effect in treating the most ...

Leggi articolo

Rheumatoid arthritis: cardiovascular benefits of anti-TNF therapy

A chronic autoimmune disease, rheumatoid arthritis is characterized by persistent inflammation of the synovial membrane and progressive joint destruction. Beyond ...

Leggi articolo

Acute coronary syndrome: patients at risk of adverse events within 3 months after stopping Clopidogrel treatment

Patients who receive the anti-platelet medication Clopidogrel ( Plavix ) following an acute coronary syndrome appear to be at greater ...

Leggi articolo

Anemic cancer patients: erythropoiesis-stimulating agents increase risk of death

A new study by Northwestern University's Feinberg School of Medicine has shown that cancer patients take drugs to boost their ...

Leggi articolo

Oral Buflomedil in the prevention of cardiovascular events in patients with peripheral arterial obstructive disease

Cardiovascular-related morbidity and mortality in patients with peripheral arterial obstructive disease remain high. LIMB study researchers performed an international, multicenter, ...

Leggi articolo

Risk of suicidal thoughts and behavior with antiepileptic drugs

The FDA ( Food and Drug Administration ) issued new information to health care professionals to alert them about an ...

Leggi articolo

Two deaths after HPV vaccine Gardasil

The EMEA ( European Medicines Agency ) has received reports of deaths in women who had previously received Gardasil, including ...

Leggi articolo

Importance of pneumococcal vaccination in cochlear implant recipients

The FDA ( Food and Drug Administration ) has informed heathcare providers regarding to life-threatening risk of bacterial meningitis in ...

Leggi articolo

Cervarix, a HPV vaccine, is not therapeutic in women with preexisting infection

Researchers have reported that women who are positive for HPV DNA, do not benefit from Cervarix, a vaccine against HPV ...

Leggi articolo

Replagal for the treatment of Fabry disease

Replagal is a solution for infusion into the body containing the active substance Agalsidase alfa. Replagal is used to treat patients ...

Leggi articolo

Golimumab improves psoriatic arthritis symptoms

Patients with active psoriatic arthritis receiving monthly subcutaneous injections of Golimumab ( CNTO 148 ) experienced significant and sustained improvements ...

Leggi articolo

DIM, a compound in broccoli, could boost immune system

A compound found in broccoli and related vegetables may have more health-boosting tricks up its sleeves. The 3,3'-diindolylmethane ( DIM ), ...

Leggi articolo

Blocking angiogenesis signaling from inside cell may lead to serious health problems

Angiogenesis inhibitors that block a tumor’s development of an independent blood supply have been touted as effective cancer fighters that ...

Leggi articolo

Hypersensitivity reactions to Pregabalin

The Australian Adverse Drug Reactions Bulletin has published a case report: four and a half hours after her first ...

Leggi articolo

Varenicline: possible effects on driving and psychiatric illness

Varenicline ( Champix ) is an aid to smoking cessation; it was launched in the United Kingdom ( UK ) ...

Leggi articolo

Zolpidem: adverse neurological and psychiatric reactions

The February 2007 Australian Adverse Drug Reactions Bulletin again alerted prescribers to an association found between Zolpidem ( Ambien, Stilnox ...

Leggi articolo

Tesamorelin reduces abdominal fat accumulation and improves lipids in HIV-infected patients

Treatment with an investigational drug that induces the release of growth hormone significantly improved the symptoms of HIV lipodystrophy, a ...

Leggi articolo

Possible role of prolactin in breast cancer

Researchers at the Kimmel Cancer Center at Jefferson in Philadelphia have discovered new molecular evidence of the role of the ...

Leggi articolo

Acute coronary syndrome therapy improvements linked with fewer deaths and improved clinical outcomes

Recent changes in the recommended treatments used for patients hospitalized for acute coronary syndromes are associated with reductions in the ...

Leggi articolo

Antidepressants: daily use of SSRIs associated with increased risk of fracture in older adults

Daily use of the antidepressant medications known as selective serotonin reuptake inhibitors ( SSRIs ) by adults 50 years and ...

Leggi articolo

Postmenopausal women: Calcium plus vitamin D supplements may help prevent weight gain

Postmenopausal women who take Calcium and Vitamin D supplements may gain less weight than those who do not, although the ...

Leggi articolo

Waist-to-hip ratio may better predict cardiovascular risk than body mass index

In a study, investigators at UT Southwestern Medical Center found that people with a larger waist-to-hip ratio may be at ...

Leggi articolo

Maternal obesity prior to pregnancy associated with birth defects

Mothers of babies born with some structural birth defects, including missing limbs, malformed hearts and underdeveloped spinal cords, appear more ...

Leggi articolo

ADHD appears to be associated with depressed dopamine activity in the brain

Adults with attention-deficit / hyperactivity disorder ( ADHD ) show a blunted response to the Methylphenidate ( Ritalin ), which ...

Leggi articolo

Fluctuating eye pressure associated with visual field deterioration in glaucoma patients

Fluctuations in eye pressure may be associated with a decreasing peripheral field of vision in patients with glaucoma, even if ...

Leggi articolo

Irinotecan plus Bevacizumab in the treatment of glioblastoma multiforme

Brain cancer patients with the poorest prognosis, those with a type of deadly tumor known as glioblastoma multiforme, may survive ...

Leggi articolo

NSAIDs and coxibs: balancing of cardiovascular and gastrointestinal risk

Gastrointestinal toxicity and cardiovascular toxicity are the two most important safety concerns for non-steroidal anti-inflammatory drugs ( NSAIDs ) and COX-2 ...

Leggi articolo

Short-acting beta-agonists associated with myocardial ischaemia

Short-acting beta-agonists are indicated for reversible airway obstruction, or prevention of premature labour, or both. Short-acting beta-agonists are available as inhalation, ...

Leggi articolo

FDA: new warning for Nonoxynol 9 OTC contraceptive products

The FDA ( Food and Drug Administration ) has required that manufacturers of over-the-counter ( OTC ) stand-alone vaginal contraceptive ...

Leggi articolo

Ace inhibitors and sartans: not for use in pregnancy

Ace ( angiotensin converting enzyme ) inhibitors and sartans ( also called angiotensin II receptor antagonists ) are licensed for ...

Leggi articolo

Computed tomography screening may increase lung cancer diagnosis, but not decrease risk of death

Screening current or former smokers with the imaging technique of computed tomography may increase the rate of diagnosis and treatment ...

Leggi articolo

Decompensated heart failure: Levosimendan does not improve survival, compared to Dobutamine

The drug Levosimendan ( Simdax ) did not improve survival for patients with decompensated heart failure when compared with a ...

Leggi articolo

Rosiglitazone and Pioglitazone: cardiovascular safety

Rosiglitazone (Avandia, Avandamet ) and Pioglitazone ( Actos, Competact ) are treatments for patients with type 2 diabetes and belong to ...

Leggi articolo

FDA has approved Kuvan for treatment of phenylketonuria

The FDA ( Food and Drug Administration ) has approved Kuvan ( Sapropterin ), the first drug of its kind ...

Leggi articolo

FDA: second safety warning on Duragesic

The FDA ( Food and Drug Administration ) issued its second safety warning about the Fentanyl transdermal system ( Duragesic ...

Leggi articolo

Recombinant human erythropoietins: new prescribing advice

Recombinant human erythropoietins ( r-HuEPOs ) are indicated for the treatment of anaemia in patients with chronic kidney disease. Some r-HuEPOs ...

Leggi articolo

Finasteride unlikely to induce high-grade prostate tumor

An increase in high-grade prostate tumor among men taking the drug Finasteride ( Proscar ) is likely caused by an ...

Leggi articolo

Supracervical hysterectomy not superior to total hysterectomy

Supracervical hysterectomy, a surgical technique that removes the uterus while leaving the cervix intact, does not have clear benefits over ...

Leggi articolo

Routine thyroid screening not recommended for pregnant women

The American College of Obstetricians and Gynecologists ( ACOG ) said there is no evidence that identifying and treating pregnant ...

Leggi articolo

Glioblastoma multiforme: Bevacizumab shows encouraging results in phase II study

A Phase II clinical study of Bevacizumab ( Avastin ), administered alone or in combination with Irinotecan ( Camptosar ...

Leggi articolo

Reports of deaths and serious cardiopulmonary reactions following the administration of ultrasound micro-bubble contrast agents

Micro-bubble ultrasound contrast agents are a sterile suspension of Perflutren gas microspheres that are indicated for use in patients with ...

Leggi articolo

FDA has approved Bystolic, a beta-blocker, to treat hypertension

The FDA ( Food and Drug Administration ) has approved Bystolic ( Nebivolol ), a beta blocker, for the ...

Leggi articolo

Acute coronary syndromes: treating depression may reduce cardiac risk

Patients with depression appear to have an impaired ability to recover their heart rate variability ( HRV ) following acute ...

Leggi articolo

Invasive breast cancer: biomarkers predict risk years before the tumor develops

A team of researchers at the University of California San Francisco ( UCSF ) has identified distinct molecular markers that ...

Leggi articolo

The WHI Dietary Modification Trial: low fat diet may lower risk of ovarian cancer

A diet low in fat could reduce the risk of ovarian cancer in healthy postmenopausal women, according to new results ...

Leggi articolo

Long-term pharmacotherapy for obesity and overweight: modest weight loss

Patients taking anti-obesity drugs will only see modest weight loss and many will remain significantly obese or overweight. The study, which ...

Leggi articolo

Serotonin receptor agonists, a faster class of antidepressants

Studies with rats have revealed the potential in an entirely new class of antidepressants that take effect after only days ...

Leggi articolo

Zolpidem and bizarre sleep related effects

Zolpidem ( Stilnox ) was marketed in Australia in late 2000 for the short term treatment of insomnia. It is ...

Leggi articolo

Citalopram, an antidepressant, has shown early promise in treating agitation and psychotic symptoms of dementia

Researchers have found surprising evidence that an antidepressant, Citalopram, may perform as well as a commonly-prescribed antipsychotic, Risperidone, in the ...

Leggi articolo

Genes linked to suicidal thinking during antidepressant treatment

Specific variations in two genes are linked to suicidal thinking that sometimes occurs in people taking the most commonly prescribed ...

Leggi articolo

HIJ-CREATE trial: Candesartan reduces the incidence of MACE in patients with impaired renal function in addition to reduction of new onset of diabetes mellitus

Researchers conducted the HIJ-CREATE ( The Heart Institute of Japan-Candesartan Randomized trial for Evaluation in Coronary Artery Disease ) trial ...

Leggi articolo

Increased mortality among patients treated with Cefepime

An article in of The Lancet Infectious Diseases has raised the question about increased mortality with the use of Cefepime ...

Leggi articolo

Transient increase in cervical cancer risk in oral contraceptive users

Current users of oral contraceptives are at increased risk of developing cervical cancer, however 10 years after stopping use the ...

Leggi articolo

Voltaren Gel for treatment of pain associated with osteoarthritis

Voltaren Gel ( Diclofenac sodium topical gel ) 1% has received FDA approval as the first topical prescription treatment that ...

Leggi articolo

Type 2 diabetes: FDA has added boxed warning for heart-related Risks to Avandia

The FDA ( Food and Drug Administration ) announced that the manufacturer of Avandia ( Rosiglitazone ), a drug used ...

Leggi articolo

FDA has approved Nexavar for patients with inoperable hepatocellular carcinoma

The FDA ( Food and Drug Administration ) has approved Nexavar ( Sorafenib ) for use in patients with a ...

Leggi articolo

FDA: Crestor approved to slow the progression of atherosclerosis in patients with elevated cholesterol

The FDA ( Food and Drug Administration ) has approved Crestor ( Rosuvastatin ) as an adjunct to diet to ...

Leggi articolo

Chronic myeloid leukaemia: Imatinib proves safe and effective over the long term

The drug Imatinib mesylate, more commonly known as Gleevec ( Europe: Glivec ), proves safe and effective over the long ...

Leggi articolo

Hepatitis C: Peginterferon alfa-2a reduces the virus but serious liver problems may progress

Patients with chronic hepatitis C and advanced liver disease who did not respond to previous standard therapy experienced significant decreases ...

Leggi articolo

Selective serotonin reuptake inhibitors can double risk of gastrointestinal bleeding

A research has shown that selective serotonin reuptake inhibitors ( SSRIs ), a group of drugs commonly used to treat ...

Leggi articolo

Rimonabant is associated with severe adverse psychiatric events

Patients given Rimonabant are at increased risk of severe psychiatric events. The prevalence of obesity continues to increase worldwide, and there ...

Leggi articolo

Pioglitazone and Rosiglitazone may reduce bone density

Thiazolidinediones include Rosiglitazone ( Avandia and Avandamet ) and Pioglitazone ( Actos ). These medicines act to increase insulin sensitivity ...

Leggi articolo

Renal impairment associated with Zoledronic acid

There is a well-known risk of deterioration in renal function with intravenous bisphosphonates administered at a rapid infusion rate. ADRAC ...

Leggi articolo

Erythropoiesis-stimulating agents: FDA has strengthened boxed warnings and has approved other safety labeling changes

The FDA ( Food and Drug Administration ) has approved revised boxed warnings and other safety-related product labeling changes for ...

Leggi articolo

STEP study: an investigational HIV vaccine is not effective

In the STEP study, one of two phase II trials of investigational HIV vaccine ( V520 ), the vaccine was ...

Leggi articolo

Drug-induced pancreatitis

Gallstones and alcohol are the two most common causes of pancreatitis, but medicines are estimated to account for about 2 ...

Leggi articolo

TNF-alpha inhibitors are associated with several serious reactions

Tumour necrosis factor alpha ( TNF-alpha ) is a cellular protein produced by the immune system and is an important ...

Leggi articolo

Novartis has proposed improving Galvus risk/benefit profile through use of approved 50 mg once-daily and twice-daily doses instead of approved 100 mg once-daily

Novartis has provided a safety update to European regulators of pooled data showing numerically less frequent liver enzyme elevations in ...

Leggi articolo

The endocannabinoid system

The endocannabinoid system was discovered through research into delta 9 –tetrahydrocannabinol ( THC ), the active ingredient in cannabis. The endocannabinoid ...

Leggi articolo

FDA has requested marketing suspension of Trasylol, an antifibrinolytic drug

The FDA ( Food and Drug Administration ) has announced that, at the agency's request, Bayer Pharmaceuticals has agreed to ...

Leggi articolo

Chronic hepatitis B: Viread more effective than Hepsera

Studies 102 and 103 have compared Viread ( Tenofovir disoproxil ) to Hepsera ( Adefovir dipivoxil ) among patients with ...

Leggi articolo

Pegasys provides hepatitis C patients a second chance to achieve a cure after not responding to Peg-Intron

Final results from the REPEAT study have demonstrated that treatment with once-weekly Pegasys ( Peginterferon alfa-2a ) and daily Copegus ...

Leggi articolo

Higher intake of fish and Vitamin-D levels linked to lower risk of age-related macular disease

Individuals who have higher dietary intake of foods with omega-3 fatty acids and higher fish consumption have a reduced risk ...

Leggi articolo

• ← Precedente
• Successivo →