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Medicine News

Medicine - Xagena Medical News

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Aggiornamento in Medicina

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Squamous cell carcinoma of oropharynx recurrence in HPV-positive patients differs from HPV-negative patients

Patients with HPV-positive squamous cell carcinoma of oropharynx ( SCCOP ) had a longer time to development of distant metastasis ...
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Selenium intake: men con V form of the SOD2 gene more likely to have an aggressive type of prostate cancer

Higher Selenium levels in the blood may worsen prostate carcinoma in some men who already have the disease. A higher risk ...
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Trichomonas vaginalis infection linked to more than two-fold increase in the risk of prostate carcinoma

A study from Harvard School of Public Health and Brigham and Women's Hospital researchers has found a strong association between ...
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Contralateral breast cancer: risk factors predicting which breast cancer patients may benefit from preventive mastectomy

A preventive procedure to remove the unaffected breast in breast tumor patients with disease in one breast may only be ...
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Long-term Tamoxifen use increases risk of ER-negative second breast cancer

While long-term Tamoxifen ( Nolvadex ) use among breast cancer survivors decreases their risk of developing the most common, less ...
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Breast cancer: Tamoxifen, Raloxifene and Tibolone can also cause serious adverse events

Three drugs that reduce a woman's chance of getting mammary carcinoma also have been shown to cause adverse effects, according ...
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Mammary carcinoma: estrogen levels following menopause may impact risk of joint pain caused by aromatase inhibitors

Aromatase inhibitors carry side effects including joint pain so severe that many patients discontinue these lifesaving medicines. New University of ...
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Metastatic colorectal cancer: better surgical interventions, new chemotherapeutic and biological agents increase 5-year survival from 8 to 30 percent

Novel chemotherapy and biological agents for metastatic colorectal cancer, combined with surgical advances in liver resection, have resulted in a ...
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Platelet transfusion strategy without routine prophylactic transfusion reduces platelet transfusion numbers significantly in patients after high-dose chemotherapy and autologous peripheral blood stem cell transplantation

This is the first randomized study showing that one-quarter to one-third of all platelet transfusions were given unnecessarily in the ...
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PLADO trial: effects of prophylactic platelet dose on transfusion outcomes

This study, the first large-scale clinical trial to compare the effects of different platelet-transfusion dosing regimens on hemostatic outcomes in ...
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Biomarkers: Lp-PLA2 and hs-CRP improve ischemic stroke prediction

Testing patient's blood for two proteins or biomarkers that occur when inflammation is present could help identify which patients are ...
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Pregnancy alone is not associated with increased risk for mental disorders

Pregnancy alone does not appear to be associated with an increased risk of the most prevalent mental disorders. However, post-partum women ...
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Vision therapy appears to improve visual function in macular disease

A low-vision therapy program that includes a home visit, counseling, assistive devices such as magnifiers and assignments to practice using ...
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Modifiable factors associated with exceptionally long life

A healthy lifestyle during the early elderly years, including weight management, exercising regularly and not smoking, may be associated with ...
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Corneal transplants: infection is an uncommon but serious complication

Corneal grafts obtained from donors dying in the hospital or with cancer may be associated with an increased risk of ...
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Multiple sclerosis: smoking Marijuana impairs cognitive function

People with multiple sclerosis who smoke Marijuana are more likely to have emotional and memory problems, according to research published ...
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HIV persists in the gut despite long-term HIV therapy

Even with effective anti-HIV therapies, physicians still have not been able to eradicate the virus from infected individuals who are ...
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Migraine associated with lower risk of breast cancer

Women who suffer from migraines may take at least some comfort in a recent, first-of-its-kind study that suggests a history ...
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Higher risk of fractures in patients with heart failure

Heart failure patients are at higher risk for fractures, including debilitating hip fractures, than other heart patients and should be ...
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Fluoroquinolones as a cause of tendon disorders

Tendon disorders, mainly tendinitis and tendon rupture, with fluoroquinolone antibiotics are well recognised. In addition to fluoroquinolone use, increasing age ...
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Hyponatraemia associated with drugs

TGA ( Therapeutic Goods Administration ) continues to receive reports of hyponatraemia in association with various medicines. Severe hyponatraemia is a ...
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CYP3A4 inhibitors may increase potential for Colchicine toxicity

Colchicine is indicated for the treatment of acute gout, but it has a narrow therapeutic index with significant potential for ...
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Small birth size linked to changes in the cardiovascular system that predispose to later disease

Researchers have found the first evidence that smaller size at birth is associated with specific alterations in the functioning of ...
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Coronary heart disease is linked to worse mental processes that predict the onset of dementia

Coronary heart disease ( CHD ) is associated with a worse performance in mental processes such as reasoning, vocabulary and ...
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Rituximab significantly reduces kidney injury in membranous nephropathy

Rituximab ( MabThera, Rituxan ) causes considerable kidney injury healing in patients with membranous nephropathy, a common form of kidney ...
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Overactive bladder: FDA has approved Toviaz

The FDA ( Food and Drug Administration ) has approved a new drug to help patients suffering from overactive bladder. ...
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Promising results in phase 1 gene therapy trial for Leber congenital amaurosis

Three young adults with an inherited form of blindness showed evidence of improved day and night vision following a specialized ...
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Glucosamine and/or Chondroitin no better than placebo in slowing structural damage of knee osteoarthritis

The dietary supplements Glucosamine and Chondroitin sulfate, together or alone, appeared to fare no better than placebo in slowing loss ...
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Refractory status epilepticus: Propofol could be fatal

Patients treated for their prolonged seizures with the sedative Propofol ( Diprivan ) may be at high risk for complications ...
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FDA: risks of life-threatening infections for psoriasis drug Raptiva

The FDA ( Food and Drug Administration ) announced labeling changes, including a Boxed Warning, to highlight the risks of ...
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Regular Salmeterol for asthma: more evidence of long-term problems

People with asthma who regularly use Salmeterol ( Serevent ) are at a greater risk of non-fatal serious adverse events ...
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Removing ovaries during hysterectomy: effects remain unknown

During hysterectomy operations, surgeons often remove a woman's ovaries as well as her uterus. Cochrane Researchers now say there is ...
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Oxygen therapy might ease pain of migraine, cluster headaches

Two types of oxygen therapy could offer some relief to adults who suffer from disabling migraine and cluster headaches, according ...
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St. John's wort relieves symptoms of major depression

New research provides support for the use of St. John's wort extracts in treating major depression. A Cochrane Systematic Review ...
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Early breast cancer: LHRH agonists show promise

Women who have had early stage breast cancer surgically removed, and whose tumour cells are stimulated by the hormone oestrogen, ...
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Eczema: there is no evidence probiotics can relieve the symptoms

There is no evidence probiotics can relieve the symptoms of eczema, but there is some evidence that they may occasionally ...
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Honey helps to heal wounds

Honey may reduce healing times in patients suffering mild to moderate burn wounds. A systematic review by Cochrane Researchers concluded ...
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Formoterol for asthma: evidence of serious adverse effects

Asthma sufferers who regularly take the beta2-agonist Formoterol ( Foradil ) are more likely to suffer non-fatal serious adverse events ...
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MC-1 does not appear to reduce risk of myocardial infarction or death following CABG surgery

Use of MC-1 ( a naturally occurring metabolite of Vitamin B6 ) before and for 30 days after coronary artery ...
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Invasive fungal infections associated with TNF-alpha inhibition

Tumor necrosis factor a ( TNF- alpha ) blockade has emerged as a useful therapy for collagen vascular diseases or ...
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FDA has approved Seroquel XR for the treatment of bipolar depression and bipolar mania

The FDA ( Food and Drug Administration ) has approved once-daily Seroquel XR ( Quetiapine fumarate ) Extended-Release Tablets for ...
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Bisphenol A is linked to heart disease and diabetes in adults

A research team from the Peninsula Medical School, the University of Exeter, the University of Plymouth and the University of ...
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Viread for chronic hepatitis B in adults

The FDA ( Food and Drug Administration ) has approved Viread ( Tenofovir disoproxil fumarate ) for the treatment of ...
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Statins do not increase the risk of amyotrophic lateral sclerosis

The FDA's analysis has provided new evidence that the use of statins does not increase incidence of amyotrophic lateral sclerosis ...
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Acute ischemic stroke: more deaths in the group of patients who received Epoetin alfa

The FDA ( Food and Drug Administration ) has been made aware of preliminary safety findings from a clinical trial ...
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Treatment with RAD001 increases time without tumour growth in patients with advanced kidney cancer

Updated study findings from the RECORD-1 ( REnal Cell cancer treatment with Oral RAD001 given Daily ) study have shown ...
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Atorvastatin lower risk of stroke for elderly people

Elderly people who take a cholesterol drug after a stroke or mini-stroke lower their risk of having another stroke just ...
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Stroke: Imatinib may reduce the risk of tPA-associated bleeding

The drug tPA is the most effective treatment currently available for stroke patients, but its safety is limited to use ...
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FDA has approved Nplate for treatment of chronic immune thrombocytopenic purpura

The FDA ( Food and Drug Administration ) has approved Nplate ( Romiplostim ), the first product that directly stimulates ...
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FDA: TNF-alpha blockers associated with risk of fungal infections

The FDA ( Food and Drug Administration ) has announced that the manufacturers of Humira ( Adalimumab ), Cimzia ( ...
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Direct intrabone transplant of unrelated cord-blood cells in acute leukaemia

Intrabone administration of unrelated umbilical-cord-blood cells overcomes the problem of graft failure seen with intravenous administration and is associated with ...
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FDA has approved Gamunex for treatment of inflammatory demyelinating polyneuropathy

The FDA ( Food and Drug Administration ) has approved an immune globulin product called Gamunex for the treatment of ...
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Methadone breaks resistance in untreatable forms of leukemia

Researchers in Germany have discovered that Methadone, an agent used to break addiction to opioid drugs, has surprising killing power ...
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FDA has approved expanded uses for Gardasil to include preventing certain vulvar and vaginal tumors

The FDA ( Food and Drug Administration ) has approved the vaccine Gardasil for the prevention of vaginal and vulvar ...
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TIME-CHF trial: intensified heart failure therapy does not improve survival free of all-cause hospitalisations in older patients

It is uncertain whether intensified, NT-BNP-guided therapy of heart failure improves outcome compared to standard, symptom-guided therapy, and whether there ...
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FDA to investigate possible Vytorin-cancer link

The FDA ( Food and Drug Administration ) is investigating a report from the SEAS trial ( Simvastatin and Ezetimibe ...
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FDA has approved Xenazine for treatment of chorea in Huntington’s disease

The FDA ( Food and Drug Administration ) has approved Xenazine ( Tetrabenazine ) for the treatment of chorea in ...
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Diabetes: cases of hemorrhagic or necrotizing pancreatitis associated with Byetta

Since October 2007, FDA ( Food and Drug Administration ) has received reports of 6 cases of hemorrhagic or necrotizing ...
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Alcohol dependence: Naltrexone associated with severe injection site reactions

The FDA ( Food and drug Administration ) has informed healthcare professionals of the risk of adverse injection site reactions ...
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Lapatinib blocks the growth of breast cancer cells that spread to the brain in a mouse model

Using laboratory and mouse models of human breast cancer, researchers have found that a small molecule capable of targeting specific ...
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Vitamin C injections slow tumor growth in mouse models

High-dose injections of Vitamin C, also known as Ascorbate or Ascorbic acid, reduced tumor weight and growth rate by about ...
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Alzheimer's disease: novel therapeutic strategies

Results from four studies of potential new treatments for Alzheimer's increase the field's knowledge and point scientists toward advances in ...
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Aortic stenosis: Vytorin does not slow progression of aortic valve disease

The SEAS ( Simvastatin and Ezetimibe in Aortic Stenosis ) study has investigated the effects of intensive cholesterol lowering with ...
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Safety concerns with fluoroquinolones: increased risk of tendinitis and tendon rupture

The FDA ( Food and Drug Administration ) has notified manufacturers of fluoroquinolone antimicrobial drugs that a Boxed Warning in ...
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Duloxetine: a review of safety reports

Duloxetine ( Cymbalta ) is a serotonin and norepinephrine reuptake inhibitor ( SNRI ) for oral administration initially approved in ...
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Serious skin reactions linked to TNF-alpha antagonists

Safety reviews of tumor necrosis factor-alpha ( TNF-a ) antagonists, Infliximab ( Remicade ), Etanercept ( Enbrel ), and Adalimumab ...
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Increased risk of death associated with off-label use of antipsychotic drugs to treat psicosis in older people with dementia

The FDA ( Food and Drug Administration ) has required manufacturers of conventional antipsychotic drugs to make safety-related changes to ...
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Insomnia: the effectiveness of Ramelteon has not been demonstrated for CHMP

The CHMP, the scientific Committee of the European Medicines Agency ( EMEA ), adopted a negative opinion, recommending the refusal ...
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Head and neck cancer: Cetuximab in combination with Docetaxel and Cisplatin as induction therapy

Patients treated for locally advanced head and neck cancer may respond better to treatment with the addition of Cetuximab ( ...
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Trasylol: access limited to investigational use

Access to Trasylol ( Aprotinin ) is limited to investigational use of the drug according to the procedures described in ...
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Metformin increases pathologic complete response rates in breast cancer patients with diabetes

Metformin ( Glucophage ), the common first-line drug for type 2 diabetes, may be effective in increasing pathologic complete response ...
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Antifibrinolytics: Aprotinin associated with increased risk of death

Aprotinin ( Trasylol ) is associated with a 50 per cent increase in the relative risk of death, according to ...
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FDA has approved Entereg to help restore bowel function following surgery

The FDA ( Food and Drug Administration ) has approved Entereg ( Alvimopan ) to accelerate the restoration of normal ...
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Topiramate linked to angle-closure glaucoma

Topiramate ( Topamax ) is an antiepileptic indicated for either monotherapy or add-on therapy in adults and in children aged ...
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POISE trial: Metoprolol increases the risk of death and stroke around the time of non-cardiac surgery

Beta-blocker drugs may help prevent myocardial infarction during surgery, but they may increase the risk of death and major stroke. POISE ...
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Tuberculosis and infections with Enbrel

Amgen and Wyeth Pharmaceuticals have added a Boxed Warning to the Enbrel ( Etanercept ) US Prescribing Information to further ...
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Evra: myocardial infarction and thromboembolic events

Evra is a transdermal hormonal contraceptive system containing 6 mg of Norelgestromin and 0.6 mg of Ethinyl Estradiol per patch. ...
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FDA: Cimzia to treat Crohn's disease approved

The FDA ( Food and Drug Administration ) has approved a new drug for treating Crohn's disease. Cimzia ( Certolizumab ...
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Intravenous immune globulin: myocardial infarction and cerebrovascular and thrombotic adverse reactions

In Canada the use of intravenous immune globulin ( IVIG ) is reported to have increased by approximately 115% over ...
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FDA has approved Amitiza for irritable bowel syndrome with constipation

The FDA ( Food and Drug Administration ) has approved Amitiza ( Lubiprostone ) for the treatment of ...
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FDA has approved Relistor for opioid-induced constipation

The FDA ( Food and Drug Administration ) has approved Relistor ( Methylnaltrexone bromide) to help restore bowel function in ...
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Diabetes: Pioglitazone and Rosiglitazone may be related to fracture risk

A widely used class of diabetes medications appears to be associated with an increased risk for fractures. “ The insulin-sensitizing thiazolidinediones ...
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Osteoporosis: Alendronate may be associated with atrial fibrillation

Alendronate ( Fosamax ), a medication used to prevent fractures in women with osteoporosis, may be associated with an increased ...
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New genetic links to psoriasis uncovered

Researchers at Washington University School of Medicine in St. Louis have discovered seven new sites of common DNA variation that ...
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Quetiapine extended release in treatment of bipolar disorder

Two randomised, double-blind, placebo-controlled studies assessed the efficacy of Quetiapine extended release ( Seroquel XR ) in patients with bipolar ...
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Antipsychotics: Olanzapine cause changes in metabolism earlier than expected

Schizophrenia is a complex type of psychotic mental illness characterized by thoughts that are uncoupled from reality. Huge gains in ...
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Anticholinergic drugs may increase cognitive decline in older people

A study looked at the effects of taking a medication with anticholinergic properties on the annual change in thinking abilities ...
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Statins may help reduce blood pressure

Statins, typically prescribed to lower blood cholesterol levels, may also modestly reduce blood pressure. Several previous studies have suggested that statins ...
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Rosuvastatin can reduce plaques that cause myocardial infarction

Findings from the ASTEROID trial showed that patients with heart disease who took the maximum dose of Rosuvastatin ( 40 ...
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Asthma: possible link between Singulair and suicide

The FDA ( Food and Drug Administration ) is investigating a possible association between the use of Singulair ( Montelukast ...
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Exubera linked to lung cancer

The Exubera label has been updated by Pfizer and FDA ( Food and Drug Administration ). The update resulted from ...
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Neuropsychiatric events linked to Relenza

GlaxoSmithKline has informed Healthcare Professionals of a recent update to the Relenza ( Xanamivir ) Inhalation Powder package insert. The ...
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FDA has approved Rotarix, a new vaccine to prevent gastroenteritis caused by rotavirus

The FDA ( Food and Drug Administration ) has approved Rotarix, a vaccine for the prevention of rotavirus, an infection ...
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Smoking is greatest predictor of recurrent cardiac events among young myocardial infarction survivors

Continuing to smoke following a myocardial infarction is the most powerful predictor for recurrent cardiac events among survivors age 35 ...
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Asthma: possible association between Singulair and behavior/mood changes, suicidality and suicide

The FDA ( Food and Drug Adminsitration ) is investigating a possible association between the use of Singulair ( Montelukast ...
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Sorafenib targets acute myeloid leukemia driven by mutant FLT3 gene

A drug used to treat kidney cancer also targets a genetic mutation active in about one third of patients with ...
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HIV-1 infection: Abacavir and Didanosine linked to increased risk of myocardial infarction

The FDA ( Food and Drug Administration ) has been made aware of recent findings from analyses of data collected ...
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Benefit of cancer prevention surgery differs between women with BRCA1 and BRCA2 mutations

The surgical removal of the ovaries has been widely adopted as a cancer-risk-reducing strategy for women with either BRCA1 or ...
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Regranex linked to an increased risk of tumor in patients with diabetes

The FDA ( Food and Drug Administration ) has received information regarding a study that was performed to investigate the ...
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Brain aneurysm: smokers treated with coils at higher risk of recurrence

Cigarette smokers who were treated for cerebral aneurysms with coil embolization are at greater risk of developing another aneurysm. In a ...
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