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Tysabri may be useful for some patients with Crohn's disease

Natalizumab ( Tysabri ), a humanized monoclonal antibody against 4 integrin, inhibits leukocyte adhesion and migration into inflamed tissue. Two ...
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Epithelial ovarian cancer, Topotecan plus Thalidomide more effective than Topotecan alone

Preliminary clinical data was reported at the XXIII Chemotherapy Foundation Symposium in New York, comparing the efficacy and safety of ...
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FDA has approved Tarceva in combination with Gemcitabine for advanced, inoperable or metastatic pancreatic cancer

The FDA ( U.S. Food and Drug Administration ) has approved Tarceva ( Erlotinib ) in combination with Gemcitabine chemotherapy ...
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Reverse genetics technique, a new way to produce flu vaccines

A team of researchers from the University of Wisconsin-Madison and the University of Tokyo has reported in the Proceedings of ...
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A genetic mechanism that controls cellular growth in fruit fly Drosophila melanogaster discovered

Researchers at Emory University School of Medicine and their colleagues have discovered a genetic mechanism that controls cellular growth in ...
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Scleroderma, Paclitaxel suppresses TGF-beta activity and reduces fibrotic tissue formation

Using a novel model for scleroderma, researchers from Duke University Medical Center have discovered two important insights into this devastating ...
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Restless legs syndrome linked to psychiatric conditions

In a study presented at Chest 2005, the 71st annual international scientific assembly of the American College of Chest Physicians ...
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Certolizumab, effective in maintaining control of the signs and symptoms of Crohn's disease following induction therapy

A single 400 mg injection of Cimzia ( Certolizumab pegol, CDP 870 ) every four weeks was effective in maintaining ...
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Diffusion MRI shows early in treatment if brain cancer therapy is effective

A study has shown that a special type of MRI scan that measures the movement of water molecules through the ...
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Vaginal gel protects the animals against an HIV-like virus

Research with female monkeys at the Tulane National Primate Research Center has for the first time shown that three different ...
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CpG-ODNs may help tumors survive

Inside the body, the reagent – CpG oligodeoxynucleotides or CpG-ODNs – alerts the body’s natural warning system to an ...
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A diuretic, Bumetanide, may suppress seizures in newborns

A study, published in the Nature Medicine, has found that Bumetanide ( Bumex ), a diuretic, may help treat seizures ...
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Tumor immunization, a new approach to enhance the immune system in patients with cancer

Researchers at Mount Sinai School of Medicine are conducting clinical trials on a unique approach to enhance the immune system ...
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Women more vulnerable to risk of colorectal cancer from tobacco

A study of gender and risk factors for colorectal cancer reveals that while both tobacco and alcohol increase risk for ...
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EphA2, a novel target for glioblastoma multiforme

Researchers at Wake Forest University Baptist Medical Center have identified a second promising treatment target for glioblastoma multiforme, one of ...
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Two enzymes, glyoxalase 1 and glutathione reductase 1, increase anxiety in mouse brains

Increasing the activity of two enzymes better known for their role in oxidative stress metabolism turns normally relaxed mice into ...
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Hepatitis C complicated by morphine withdrawal

Researchers at the University of Pennsylvania have demonstrated that Morphine withdrawal complicates hepatitis C by suppressing IFN-alpha-mediated immunity and enhancing ...
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Risk of ischemic stroke increases with rise in particulate air pollution

A study, led by researchers at Beth Israel Deaconess Medical Center ( BIDMC ) and the Harvard School of Public ...
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DCDC2 gene associated with dyslexia

Researchers at Yale School of Medicine have identified a gene on human chromosome 6 called DCDC2, which is linked to ...
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Regular physical activity may strenghten knee cartilage

Osteoarthritis is the leading cause of disability among adults. As the population ages, increased intervention efforts are vital to controlling the ...
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Measles immunization may prevent fatal brain infection

A study has found wild-type measles virus in tissues from patients who died of a fatal brain infection, providing evidence ...
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Poor pregnancy outcomes linked to increased uric acid

Researchers at the University of Pittsburgh have found that pregnant women with hypertension who also have elevated blood uric acid ...
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Hormone PYY can inhibit eating in the morning, but not in the evening

A research at the Oregon National Primate Research Center ( ONPRC ) at Oregon Health & Science University has demonstrated ...
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Terminating an unwanted first pregnancy does not raise risk of depression

A longitudinal cohort study has shown that terminating an unwanted first pregnancy may be linked to a lower risk of ...
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Environment is a major factor in addiction recovery

A research in monkeys suggests that, although living in an "enriched" environment can make someone less vulnerable to abusing cocaine, ...
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A specific type of neuron that is essential for feeding behavior identified

Working with mice -- whose appetites are controlled by systems very similar to those in humans – researchers have identified ...
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EBF-1 gene might be involved in multiple sclerosis

A gene involved in B-cell development might play a role in multiple sclerosis. The results of a large study published in ...
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Fused genes trigger the development of prostate cancer

Researchers at the University of Michigan ( U-M ) Medical School, in collaboration with researchers at Harvard's Brigham and Women's ...
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HapMap Consortium has published map of human genetic variation

The International HapMap Consortium published a comprehensive catalog of human genetic variation, a landmark achievement that is already accelerating the ...
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Studies on human genome variation provide insight into disease

The International HapMap Project was initiated with the primary goal of facilitating medical studies and understanding the genomic basis for ...
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Bladder function can worsen in men as they age

Researchers at Mayo Clinic studying prostate problems in men report in the Journal of Urology that as men grow older ...
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Cystic fibrosis, little evidence exists to support the widespread use of bronchodilators

Little evidence exists to support the widespread use of bronchodilators to treat children and adults with cystic fibrosis. “ Recurrent wheeze ...
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Gene therapy reverses genetic mutation responsible for heart failure in an animal model

Researchers at the University of Pittsburgh have for the first time used gene therapy to successfully treat heart failure and ...
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Role of Smoothened and primary cilium in Hedgehog signaling

Researchers at the University of California - San Francisco ( UCSF ) have found a key step in a signaling ...
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Use of pneumococcal conjugate vaccine in children can affect pneumonia transmission in community

The incidence of pneumonia among older adults has decreased substantially, linked to the introduction of a pneumonia vaccine for children ...
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Measuring telomerase activity in urine appears useful for detection of bladder cancer in men

Measurement of an enzyme level ( telomerase activity ) in urine appears useful for detection of bladder cancer in men. The ...
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Surgery, reduced risk of wound infection in patients receiving supplemental oxygen

Patients who received a higher concentration of supplemental oxygen during colorectal surgery had a significantly reduced risk of wound infection. Surgical ...
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Growth hormone illegal for off-label anti-aging use

Human growth hormone, or HGH, is a substance released by the pituitary gland that spurs growth and development in children ...
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SPRN6 gene that helps mosquitoes fight off malaria parasite identified

Researchers have identified a gene in mosquitoes that helps the insects to fight off infection by the Plasmodium parasite, which ...
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Lipid-lowering drugs are not associated with breast cancer risk

A study has shown that cholesterol levels and use of statins or other lipid-lowering drugs are not associated with breast ...
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Anemia associated with higher risk of death in the elderly

A study has demonstrated that elderly people with the lowest and highest hemoglobin concentrations are at increased risk of death. Increasing ...
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Facial expressions reveal how the body reacts to stress

A provocative study has found that people who respond to stressful situations with angry facial expressions, rather than fearful expressions, ...
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Zevalin regimen associated with severe cutaneous or mucocutaneous reactions

Biogen Idec has informed Healthcare Professional of new safety information which is being added to the prescribing information for ...
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Acute ischemic stroke, patient enrollment permanently discontinued in phase 3 trial of ReoPro

Patient enrollment in the phase 3 trial of ReoPro ( Abciximab ) for the treatment of acute ischemic stroke has ...
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Xolair, the first monoclonal antibody approved for the treatment of severe allergic asthma in Europe

European Commission has granted marketing authorization in all 25 EU member states for the novel asthma therapy Xolair ( Omalizumab ...
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Aprotinin decreases hyperglycemia and insulin resistance in cardiac surgical patients

A research team at Columbia University Medical Center has completed the first human study to show that Aprotinin, a protease ...
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p27SJ, a protein in St.John’s wort, suppresses HIV-1 expression

Researchers at Temple University School of Medicine discovered that a novel protein, p27SJ, extracted from a callus culture of the ...
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Efficacy of Cold-fX in the prevention and relief of cold and flu infections

A study has shown that Cold-fX, an anti-flu, anti-cold pill, reduced the incidence and frequency of recurrent colds by more ...
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Pertussis, adolescents and adults susceptible to the infection

Researchers at Saint Louis University have demonstrated that immunization with a new vaccine could potentially prevent more than a million ...
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Psychological and social impacts of contralateral prophylactic mastectomy

Researchers at the Mayo Clinic have found that that most women who have a contralateral prophylactic mastectomy are satisfied and ...
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Sildenafil blunts effects of stress on the human heart

Researchers at Johns Hopkins found that Viagra ( Sildenafil ), a drug used to treat erectile dysfunction ( ED ), ...
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Survival benefits of longer-term Tamoxifen therapy may take years to appear

A study showed that the survival benefits of longer-term therapy using Tamoxifen may take at least nine years to develop. A ...
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Circumcision may offer some protection against HIV transmission

A trial found that circumcision reduces the rate of new infections among heterosexual men in South Africa by about 60%. ...
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Botulinum toxin may be useful for trigeminal neuralgia

Botulinum toxin can also successfully treat intense facial pain called trigeminal neuralgia. Trigeminal neuralgia is a disorder characterized by sudden, severe, ...
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NK-1 receptor antagonist more effective at reducing vomiting after surgery than Ondansetron

The results of a Phase III clinical trial have demonstrated that a new class of drugs, called NK-1 receptor antagonists, ...
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An acid-sensing cellular receptor might have clinical relevance in arthritis, heart attack, stroke

Karin Westlund and Terry McNearney, at the University of Texas Medical Branch ( UTMB ) in Galveston, noted that " ...
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BOLDER II study confirms therapeutic potential of Seroquel in major depressive episodes associated with bipolar disorder

Results from the BOLDER II ( BipOLar DepRession ) study have underlined the potential for Seroquel ( Quetiapine ) ...
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Testosterone therapy improves sexual function in post-menopausal women

A systematic review found that the addition of Testosterone to hormone therapy in women after menopause enhances their sexual function. However, ...
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Local anesthetics are effective for neuropathic pain

A systematic review of current evidence has shown that Lidocaine and similar local anesthetics are effective for treating pain that ...
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Persistent cough treatments for children may not be the most effective

Two reviews of previous medical studies suggest that traditional medical treatment of persistent cough may not be the most effective. ...
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Inhaled nitric oxide may help sickle cell disease

Researchers at the Medical College of Georgia have found that nitric oxide may help normalize a sickle cell patient’s hemoglobin ...
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Exercise improves cardiopulmonary fitness in asthma

A review of studies has found that exercise improved cardiopulmonary fitness in people with asthma. " It's safe for patients with ...
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Menin in the development of some forms of acute leukemia

Tumor-suppressor proteins work to inhibit tumor growth in our bodies and when they win, they spare us a battle with ...
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New gene regulation mechanism discovered

Researchers at Cold Spring Harbor Laboratory have discovered a new kind of messenger RNA molecule that is converted from non-protein ...
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Prenatal exposure to alcohol may cause visual problems in infants

Fetal alcohol syndrome ( FAS ), a disorder that is indicated by distinct facial characteristics, growth retardation, and poor intellectual ...
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Molecular mechanism of cocaine addiction

In the journal Neuron, researchers led by Eric J. Nestler and Arvind Kumar of The University of Texas Southwestern Medical ...
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Multiple sclerosis progression linked to MIF

A study suggests that a substance made by immune cells plays a key role in the progression of a disease ...
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No link between the MMR vaccine and any long-term disability

There was no credible evidence behind claims of harm from the MMR ( measles, mumps and rubella ) vaccination. This ...
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Junk DNA has evolutionary importance in Drosophila

Peter Andolfatto, an assistant professor of biology at University of California - San Diego ( UCSD ), has showed ...
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Genetic cause of speech defect discovered

Researchers at the University of Toronto, Capital Health's Stollery Children's Hospital in Edmonton, Toronto's Hospital for Sick Children and their ...
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Risk of melanoma in CDKN2A mutation carriers lower than estimated

People who carry a mutation in the melanoma susceptibility gene CDKN2A have a much lower risk of melanoma than has ...
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CD19 monoclonal antibody could treat leukemias, autoimmune diseases, transplant rejection

In studies with mice, treatment with a new monoclonal antibody that targets immune system B cells has shown considerable promise ...
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Violent video games lead to brain activity characteristic of aggression

Researchers at Michigan State University ( MSU ) have shown that playing violent video games leads to brain activity pattern ...
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Vanadium appears to play role in speeding recovery from infections

Dietary supplements containing vanadium are used by body builders to help beef up muscles and by some diabetic people to ...
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SCD1 gene makes muscles in the obese store more fat

Researchers from Duke University Medical Center and Louisiana State University have found that the gene encoding an enzyme that hinders ...
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Erectile dysfunction may signal early atherosclerosis

Erectile dysfunction may be a sign that coronary artery disease is developing, even in men without typical risk factors. " We ...
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Acute coronary syndromes, adherence to treatment guidelines declines as patient age increases

A review of more than 56,000 cases of acute coronary syndromes reveals that older patients are less likely to receive ...
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Zemiva, an experimental radioactive compound reveals metabolic disturbances in the heart

Researchers, led by Vasken Dilsizian at the University of Maryland Medical Center, has demonstrated for the first time that an ...
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Tuberculosis, transmission is linked to historical patterns of human migration

Genghis Khan and his troops may have unwittingly used more than just brute military force to conquer entire nations and ...
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Septin-9 gene mutations linked to hereditary neuralgic amyotrophy

A team of researchers has discovered gene mutations associated with an inherited chronic pain and weakness syndrome known as hereditary ...
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Elevated GGT enzyme may predict risk of death from cardiovascular disease

A simple blood test may identify people who have an increased risk of dying from cardiovascular disease. The test measures gamma-glutamyl ...
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Statins associated with lower risk of fractures

In a study of elderly, predominately male veterans, statin use was associated with a 36 percent reduction in risk of ...
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Three new genetic mutations in brain tumors identified

Researchers at Johns Hopkins have identified three new genetic mutations in brain tumors, a discovery that could pave the way ...
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Muraglitazar increases the risk for morbidity and mortality in diabetic patients

Peroxisome proliferator–activated receptors ( PPARs ) are ligand-activated nuclear transcription factors that modulate expression of a large number of genes. In ...
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Bariatric surgery, risk of death is higher among men and older patients

Medicare patients have a substantially higher risk of early death following bariatric surgery than previously suggested, and the risk of ...
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Lung cancer, restoring the missing or silenced WWOX gene can slow or stop the cells' growth

A study suggests that restoring a gene often silenced in lung cancer causes the cells to self-destruct. The research focused on ...
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Prostate cancer, identified how 1G8 antibody blocks growth in animal models

Researchers at University of California - Los Angeles ( UCLA ) - Jonsson Cancer Center have uncovered the mechanism by ...
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A hormone might cause preeclampsia

Researchers at the University of Cincinnati ( UC ) Academic Health Center have found evidence of a hormone they say ...
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Cystic fibrosis, breath test offers hope for early detection of lung-bacteria growth

Researchers at University of California - Irvine ( UCI ) have found that breath-analysis testing may prove to be an ...
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Rett syndrome, MeCP2 gene regulates alternative splicing

The gene responsible for Rett syndrome not only silences some genes but in combination with another also regulates alternative splicing, ...
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Physically abused boys may be more likely to commit domestic violence as adults

A history of childhood physical abuse may be common in men from urban settings, and these men with physical abuse ...
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Smoking reduces fertility in men

Sperm from nearly two-thirds of the chronic smokers in the study failed a special test that measures the ability of ...
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Corticosteroids often used in treatment of infectious mononucleosis

Corticosteroids are used often in the treatment of infectious mononucleosis, and for reasons beyond usual criteria. Systemic corticosteroid therapy ( SCT ...
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Laparoscopic surgery effective in treatment of severe reflux disease

Laparoscopic surgery to treat severe reflux disease is effective in relieving symptoms and is associated with high rates of patient ...
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Infertility, critical role of GlcNAc-6-OST gene in the human embryo implantation process

Researchers at Cedars-Sinai Medical Center and the University of California at Los Angeles conducted a study regarding molecular mechanism involved ...
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Integration of cell survival signals in PTEN-deficient tumors

A study has identified a molecular switch that integrates cell survival signals from multiple intracellular signaling pathways. The finding has substantial ...
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Herceptin plus adjuvant chemotherapy improves outcomes among women with surgically removed HER2-positive breast cancer

Researchers have presented the combined results of two trials that compared adjuvant chemotherapy with or without concurrent Herceptin ( Trastuzumab ...
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Early-stage breast cancer, Herceptin after adjuvant chemotherapy improves disease-free survival

Herceptin ( Trastuzumab ), a recombinant monoclonal antibody against HER2, previously shown to prolong survival in advanced breast cancer, reduced ...
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Mechanisms leading to portal hypertension identified

Researchers at UT Southwestern Medical Center have identified mechanisms causing a potentially deadly type of hypertension that results from liver ...
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Only one-third of women take folic acid to help prevent serious birth defects

Only one-third of childbearing age women are taking a multivitamin containing the B vitamin folic acid daily to prevent serious ...
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