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Cocaine and amphetamine require CART, an neurotransmitter, to produce their maximal effects

A study led by Pastor R. Couceyro, at Rosalind Franklin University of Medicine and Science and colleagues at Amgen sheds ...
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Type 2 diabetes, treatment with Starlix and Metformin results in a lower incidence of hypoglycemia compared to therapy with Glyburide and Metformin

Researchers reported that in a two-year, controlled study people with type 2 diabetes receiving Starlix ( Nateglinide ) in combination ...
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Monoclonal antibody for treating mice infected with West Nile virus identified

A monoclonal antibody that can effectively treat mice infected with West Nile virus has an intriguing secret: contrary to scientists' ...
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Positive results of a gene therapy clinical trial for patients with Parkinson's disease

Investigators reported positive interim results of a gene therapy clinical trial for patients with Parkinson's disease. Neurologix's 12-patient, dose-escalating Phase ...
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Plectasin, a new fungal defensin, plectasin, is effective against drug-resistant bacteria

A peptide identified in a fungus found in northern European pine forests possesses as much power as Penicillin as well ...
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Elevated blood levels of osteopontin linked to pleural mesothelioma

Researchers at New York University ( NYU ) School of Medicine and Wayne State University have found a molecule ...
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FDA approves Aromasin for adjuvant treatment of early breast cancer in postmenopausal women

The FDA ( U.S. Food and Drug Administration ) approved Aromasin ( Exemestane tablets ) for adjuvant treatment of postmenopausal ...
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FDA approves Humira for first-line treatment of moderate to severe rheumatoid arthritis

The FDA ( U.S. Food and Drug Administration ) approved Humira ( Adalimumab ) for first-line treatment of recent onset ...
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Benefits of Elidel in eczema patients who require an alternative to conventional steroid treatment

A study has shown the importance of Elidel ( Pimecrolimus ) cream 1% as an alternative to topical corticosteroids. Elidel cleared ...
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Diabetes, Exubera receives positive opinion from CHMP

The Committee for Medicinal Products for Human Use of the European Medicines Agency ( CHMP ) issued a positive opinion ...
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Prasugrel demonstrates more consistent platelet inhibition compared to Clopidogrel ( early-phase data )

Results from three early-phase, cross-over studies demonstrated that all subjects responded to Prasugrel, an investigational antiplatelet agent, while 22 to ...
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Very low LDL cholesterol levels appear to be safe for patients on intensive therapy

Very low LDL cholesterol levels appear to be safe for heart patients on statin therapies. " There was no apparent ...
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End-stage renal disease, prognosis for patients with diabetes improved

Patients with type 1 diabetes have an improved prognosis with regard to end-stage renal disease over the past four decades, ...
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Decline in total cholesterol level among US adults

The total cholesterol level among older adults has declined significantly, while there has been little change among younger adults. Serum total ...
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Muscle bears a metabolic memory of obesity

A study suggest that muscle bears a metabolic memory of obesity, which may help to explain why sustained weight loss ...
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Heart failure patients have impaired cooling response

Researchers at the University of Texas ( UT ) Southwestern Medical Center have found that reduced blood flow to the ...
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Heme controls antioxidants and iron in ferritin

A study conducted by scientists at Children's Hospital Oakland Research Institute could help researchers develop new treatments for a variety ...
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IL-1ra protects brain cells from injury and death

Researchers at the University of Manchester ( UK ) have shown in laboratory studies that a naturally occurring protein called ...
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Phenylketonuria in mice cured with new gene therapy technique

Researchers at the Mount Sinai School of Medicine developed a technique for inserting genes into specific sites on the genome ...
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Newborns' exposure to toxic substances could be behind sharp rises in asthma, allergies and lupus

Exposure of fetuses and newborns to low levels of environmental poisons such as lead, mercury and dioxin, as well as ...
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Astrocytes are directly involved in regulating communication between neurons

Researchers at the University of Pennsylvania School of Medicine have demonstrated that star-shaped glial cells in the brain called astrocytes ...
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Concussions promote dementias in retired professional football players

A study suggests that repeated concussions brought on by blows to the head during their playing days significantly boost the ...
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FGF15 controls the production of bile acid

A newly discovered hormone plays an important role in the digestion of fat, cholesterol, and fat-soluble vitamins, such as vitamins ...
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AIDS, antiretroviral drugs don't halt brain damage

A imaging study carried out at UCLA/University of Pittsburgh for the first time has showen the selective pattern of destruction ...
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Doubts on widespread use of C-reactive protein test to assess cardiovascular risk

Widespread screening for cardiovascular risk by measuring blood levels of C-reactive protein ( CRP ), a protein produced by the ...
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Risk of dementia and Alzheimer's disease associated with midlife obesity

A research, published in the Archives of Neurology, showed that subjects who were obese at midlife had an increased risk ...
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Consuming fish is associated with slower cognitive decline

A study found that consuming fish at least once a week was associated with a 10 percent per year slower ...
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Depression seems to increase the risk for developing epilepsy

A study, led by researchers from Columbia University, New York, found provocative evidence that the brain dysfunction that underlies ...
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Moderate exercise yields cardiovascular benefits

A analysis of the first randomized clinical trial evaluating the effects of exercise amount and intensity in sedentary overweight men ...
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Respiratory viral infections, CCL5 protein protects macrophages from death

Immune cells called macrophages consume virus-infected cells to stop the spread of the disease in the body. Rresearchers at Washington University ...
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Patients with melanoma are at increased risk for new tumors

Researchers at the Memorial Sloan-Kettering Cancer Center ( MSKCC ) have found that melanoma patients with a family history of ...
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GRK5 has an important role behind essential hypertension

When Andrea Eckhart, at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and her co-workers turned up the volume ...
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Actos may not reduce macrovascular events in patients with type 2 diabetes

Patients with type 2 diabetes are at high risk of fatal and non-fatal myocardial infarction and stroke. There is indirect ...
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Statins suspected of being associated with memory loss

The role of HMG-CoA reductase inhibitors, or statins, in cardiovascular protection is well established. However, evidence in the current literature ...
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Avian influenza A ( H5N1 ): Health Canada’s recommendations

The Ministry of Health in Indonesia confirmed another fatal human case of H5N1 avian influenza. The patient, a 27-year-old woman ...
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Cystic fibrosis, subtle genetic variations influence severity

A study found that subtle differences in other genes, besides the defective gene known to cause the illness cystic fibrosis, ...
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1918 Spanish flu virus reconstructed and characterized

For the first time, the deadly 1918 Spanish flu virus has been reconstructed and characterized. The research, reported in the journal ...
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Defects in adult stem cell niche may cause breast cancer

Researchers at Georgetown’s Lombardi Comprehensive Cancer Center have found that the onset of breast cancer may be due to defects ...
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Gardasil prevents cervical pre-cancers and non-invasive cervical cancers associated with HPV types 16 and 18

Gardasil ( quadrivalent human papillomavirus types 6, 11, 16, 18, recombinant vaccine ), an investigational vaccine, prevented 100 percent of ...
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Actos reduces heart attacks, strokes and deaths in patients with type 2 diabetes

Data from the PROactive Study, presented at the 41st meeting of the European Association for the Study of Diabetes ( ...
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High blood glucose levels in early pregnancy may deprive embryo of oxygen and lead to birth defects

Newborns of women with diabetes are two to five times more likely to develop birth defects than offspring of women ...
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ReoPro for acute ischemic stroke: patient enrollment temporarily suspended in AbESTT-II trial

The enrollment in the Abciximab in Emergent Stroke Treatment Trial-II ( AbESTT-II ), the phase III trial of ReoPro ( ...
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Long-acting beta-2 agonists linked to increased risks of asthma-related deaths

The use of a class of asthma drugs known as long-acting beta-2 agonists is associated with increased risks of asthma-related ...
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TGFBR1*6A may represent a potential therapeutic target in cancer

A relatively common cancer susceptibility gene appears to be frequently acquired in metastatic lesions from colorectal cancer, and give cancer ...
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Genetic instability and accumulations of mutations lead to disease

Mayo Clinic researchers have discovered the inner workings of a defective DNA repair process and are first to explain why ...
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Concerta effective for long-term ADHD treatment

A study has found that an all-day, extended-release stimulant for treating attention-deficit hyperactivity disorder ( ADHD ) remains effective for ...
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Strong relationship of major depressive disorder to substance dependence found

Epidemiologic Survey of Alcohol and Related Conditions ( NESARC ) has showed for the first time that middle age and ...
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Synthetic PLAD protein reduce arthritis symptoms in mice

Synthetic PLAD protein alleviates symptoms of both acute and chronic arthritis in mice and could be the basis for a ...
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Pulmonary artery catheter in critically ill patients has neutral effect

A meta-analysis of previous studies indicates that use of a pulmonary artery catheter ( PAC ) in critically ill patients ...
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Risk of breast cancer for young women treated for Hodgkin lymphoma

Young women who are treated for Hodgkin lymphoma with chest radiation therapy have a high cumulative absolute risk of developing ...
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Pulmonary artery catheterization does not show benefit for severe heart failure patients

Hospitalized patients with severe congestive heart failure did not experience a benefit from use of pulmonary artery catheterization, but had ...
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Immune-mediated haemolytic anemia after Raptiva treatment

Raptiva ( Efalizumab) is indicated for the treatment of adult patients ( 18 years or older ) with chronic moderate ...
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ADHD, increased risk of suicidal thinking for Strattera

FDA ( U.S. Food and Drug Administration ) has issued a Public Health Advisory to alert physicians of reports of ...
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Five reports of Guillain Barre syndrome following administration of Menactra

FDA ( U.S. Food and Drug Administration ) and CDC ( Centers for Disease Control and Prevention ) are alerting ...
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Increased risk of congenital malformations associated with use of Paroxetine

GlaxoSmithKline ( GSK ) conducted a retrospective epidemiologic study of major congenital malformations in infants born to women taking antidepressants ...
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Lipitor approved to reduce stroke and heart attack risk in people with type 2 diabetes

The FDA ( U.S. Food and Drug Administration ) has approved Lipitor ( Atorvastatin ) a cholesterol-lowering drug, to reduce ...
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FDA Panel recommends approval of Exjade for once-daily oral treatment of chronic iron overload due to blood transfusions

Blood Products Advisory Committee ( BPAC ) of the FDA ( U.S. Food and Drug Administration ) has given a ...
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KLF2 protein is crucial for normal development and regulation of red blood cells

Researchers at the Virginia Commonwealth University ( VCU ) studying hemoglobin genes, mutations of which play a role in genetic ...
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Liver transplantation due to Hepatitis C: alpha-SMA, a biomarker, predicts recurrence of disease

Two studies on hepatitis C ( HCV ) patients who underwent liver transplants examined a potential biomarker that could be ...
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High fat diet alters hepatic immune system in mice

Mice that were fed diets high in fat and sugar developed immune system abnormalities in their livers, including reduced numbers ...
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Psoriatic arthritis, FDA approves Humira for reducing signs and symptoms of active arthritis

FDA ( U.S. Food and Drug Administration ) approved Humira ( Adalimumab ) for reducing signs and symptoms of active ...
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Relapsing multiple sclerosis, FTY720 shows sustained benefits and good tolerability

Data from the extension of a Phase II study to 12 months confirmed the effects of FTY720, a new immunomodulator, ...
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Acute coronary syndrome, gene variants linked to increased risk of death in patients treated with beta-blockers

Patients with certain gene variants who were prescribed beta-blocker drugs after acute coronary syndrome ( ACS ) had an increased ...
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Long-term smoking is associated with up to 40 percent increased risk of breast cancer

Researchers at Fred Hutchinson Cancer Research Center found that older women who have smoked for 11 or more "pack years" ...
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Langat flavivirus, NS5 allows to evade the host immune system

Researchers from the National Institute of Allergy and Infectious Diseases ( NIAID ), part of the National Institutes of Health ...
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Hematopoietic-cell transplantation, protective conditioning protects against GVHD

Conditioning with total lymphoid irradiation plus antithymocyte serum protects mice against acute graft-versus-host disease ( GVHD ) after hematopoietic-cell transplantation. ...
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Flavanol-rich cocoa drink improves blood vessel function in smokers

A study, published in the Journal of the American College of Cardiology, found that phytochemicals known as flavanols, which ...
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Phytoestrogens linked to lower lung cancer risk

A diet higher in plant-derived compounds known as phytoestrogens seems to be linked with a lower lung cancer risk. Phytoestrogens are ...
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ADHD, Strattera linked to increased risk of suicidal thinking

FDA ( Food and Drug Administration ) has received reports of suicidal thinking in children and adolescents associated with Strattera ...
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Alert on Menactra meningococcal vaccine: 5 reports of Guillain Barre syndrome

FDA ( Food and Drug Administration ) has received five reports of Guillain Barre syndrome, following administration of Meningococcal Conjugate ...
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Juice of the pomegranate could combat prostate cancer

Researchers at University of Wisconsin ( UW ) Medical School demonstrated that the juice of the pomegranate could combat ...
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Gene that may control risk-taking behavior identified

Researchers at Fred Hutchinson Cancer Research Center have found that a specific neurodevelopmental gene, called neuroD2, is related to the ...
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Loss of body mass linked to development of Alzheimer's disease

A research found that loss of body mass over time appears to be strongly linked to older adults' risk of ...
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Hutchinson-Gilford progeria syndrome, farnesyl transferase inhibitors might reverse disease

Researchers at the Johns Hopkins have discovered that a drug currently being tested against cancers might help children with a ...
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Family history may be the most effective measure for cancer risk

One in five women diagnosed with breast or ovarian cancer who seek mammography have a family history of cancer that ...
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Higher cancer risk for kidney transplant patients

People who receive a kidney transplant are nearly four times more likely to develop melanoma, a rare but deadly form ...
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Human beta-cell line offers hope for type 1 diabetes treatment

Transplantation of insulin-producing pancreatic beta-cells shows great promise as a treatment for type 1 diabetes, but development of this therapy ...
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Smoking may increase risk of diabetes

A research by investigators at Wake Forest University School of Medicine and colleagues demonstrated that smoking may increase the risk ...
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Carotid endarterectomy beneficial for stroke prevention in some patients

New guideline, published in the Neurology, has updated the 1990 AAN ( American Academy of Neurology ) statement on carotid ...
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Long-term benefits of Xolair for patients with severe allergic asthma

Long-term data show that Xolair ( Omalizumab ), a first-in-class monoclonal antibody for treating severe allergic asthma, helped patients to ...
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Novartis, new products portfolio

Novartis has a comprehensive portfolio of cardiovascular products both in the market ( Diovan and Lotrel ) as well as ...
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Statin therapy can reduce the incidence of major coronary events and stroke

Results of previous randomised trials have shown that interventions that lower LDL cholesterol concentrations can significantly reduce the incidence of ...
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Defect in a gene of the Septin family causes neuralgic amyotrophy

Researchers from the Flanders Interuniversity Institute for Biotechnology ( VIB ) connected to the University of Antwerp, have uncovered a ...
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Lead exposure plus high blood pressure may impair mental ability

A study presented at the 2005 American Heart Association's High Blood Pressure Research Meeting has showed that exposure to lead ...
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Molecular origin of polyglutamine diseases

Researchers at the University of North Carolina ( UNC ) at Chapel Hill School of Medicine points to the possible ...
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IL-6 linked to transverse myelitis and multiple sclerosis

Researchers at Johns Hopkins have discovered a single molecule that is a cause of an autoimmune disease in the central ...
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Severe Staphylococcus aureus infections in small children

Researchers at the University of Chicago described three cases of rapidly progressive and ultimately fatal Staphylococcus aureus infections in small ...
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Cancer vaccines: discovered how to dramatically boost the immune system

Researchers at Mayo Clinic have discovered a way to dramatically boost the output of immune system cells from the thymus, ...
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Insulin's role in blocking release of energy in patients with type II diabetes

Researchers at the University of California, San Diego ( UCSD ) School of Medicine discovered that chronically high levels of ...
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Aquaporin-4, water channel protein implicated in a disorder similar to multiple sclerosis

Researchers have identified a molecular suspect in a disorder similar to multiple sclerosis ( MS ) that attacks the optic ...
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A cluster of genes on chromosome six plays a significant role in multiple sclerosis

A genetic study found that a cluster of genes on chromosome six is the only one that plays a significant ...
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Strategies to raise levels of HDL cholesterol

Experts at Johns Hopkins have issued interim guidelines for physicians on how best to treat low levels of HDL cholesterol. In ...
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New blood test for prostate cancer more accurate than PSA developed

Researchers at the University of Michigan Comprehensive Cancer Center have identified a panel of 22 biomarkers that together provide a ...
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Childhood asthma linked to exposure to traffic-related pollution

For children living near a freeway may bring an increased risk of asthma, according to researchers at the Keck School ...
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Beta-carotene linked to higher risk of some cancers in women smokers but not nonsmokers

A study has found that high beta-carotene intake--through a combination of diet or supplementation--is associated with a higher risk of ...
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Change in DNA repair gene MGMT may be underlying molecular defect in some colorectal cancers

A study, published in the Journal of the National Cancer Institute, found that inactivation of a DNA repair gene ...
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EGCG, a green tea ingredient, prevents Alzheimer's-like brain damage in mice

Researchers at the University of South ( USF ) have found that green tea may offer another potential health benefit ...
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Tunneling nanotubules discovered as means for communication between immune system cells

Researchers at the University of Pittsburgh School of Medicine discovered that immune system cells are connected to each other by ...
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Viral-based therapies for cancer

Researchers at Columbia University Medical Center continue to make progress in developing effective viral-based therapies for cancer. Two papers about promising ...
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Tunneling nanotubules discovered as means for communication between immune system cells

Researchers at the University of Pittsburgh School of Medicine discovered that immune system cells are connected to each other by ...
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