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Second-generation antidepressants very similar but have different side effects

Many second-generation antidepressants, despite differences in drug classification and cost, offer patients essentially the same benefits with little variation in ...
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Defective lymphatic vessels identified as a novel cause of adult-onset obesity

Laboratory model missing one copy of Prox1 gene exhibits abnormal increase in fat accumulation around sites of lymph leakage from ...
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A molecular pathway that leads to recurrence of breast cancer discovered

Using a mouse model of breast cancer, researchers from the University of Pennsylvania School of Medicine have shown that Snail, ...
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hVps34, a new target in fight against obesity and diabetes

Researchers at the University of Cincinnati ( UC ) have identified a possible new target for treating obesity and diabetes. ...
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Schizophrenia: CATIE study compares the effectiveness and side effects of five medications

A large study, Clinical Antipsychotic Trials of Intervention Effectiveness ( CATIE ), funded by NIH's National Institute of Mental Health ...
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A molecular defect in cardiac cells that may cause of heart failure found

A study has identified a molecular defect in cardiac cells that may be a fundamental cause of heart failure, a ...
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Antibiotics for acne may increase risk of common infectious illness

Subjects treated with antibiotics for acne for more than six weeks were more than twice as likely to develop an ...
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Adult human neural stem cell therapy successful in treating spinal cord injury

Researchers at the University of California - Irvine Reeve-Irvine Research Center have used adult human neural stem cells to successfully ...
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Advanced non-small cell lung cancer, Tarceva benefits older patients

According to Researchers from Dana-Farber Cancer Institute in Boston, Tarceva ( Erlotinib ), a tyrosine kinase inhibitor, showed encouraging activity ...
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A simpler method for using modified viruses to transport therapeutic genes to tumors discovered

Researchers at the Mayo Clinic have devised a new virus-based gene therapy delivery system to help fight cancer. Researchers say ...
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Women with dense breasts, women younger than 50, and those who are perimenopausal may benefit from digital mammograms

Preliminary results from clinical trial of digital versus film mammography show no difference in detecting breast cancer for the general ...
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Overall health and quality of life intact 10 years after stem-cell transplantation

The study found that survivors of stem-cell transplantation for blood cancers and case-matched controls reported similar rates of hospitalization and ...
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Less virulent strains of avian influenza can infect humans

A research, published in The Journal of Infectious Diseases, reported for the first time that a less-virulent strain of avian ...
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Cardiac stress tests help identify people at risk of developing coronary heart disease

A team of cardiologists at Johns Hopkins reported that performing cardiac stress tests that measure exercise capacity and heart rate ...
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Hemoglobin A1c predicts heart disease risk in both diabetics and non-diabetics

Researchers at the Johns Hopkins Bloomberg School of Public Health and other institutions, believe that lowering blood glucose levels could ...
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Heart failure, patients at greatest risk of death least likely to receive appropriate medications

Heart failure is associated with a high death rate. Medications shown to reduce the risk of illness and death from this ...
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A switch allows preadipocytes to form fat cells

Researchers, at University of Michigan Life Sciences Institute, found that a hormonal cocktail routinely used in the lab induces a ...
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Low-dose Aspirin might prevent the cardiac damage of Cox-2 inhibitors

An animal study, published in the journal Cell Metabolism, found that the increased rate of cardiovascular complications in patients taking ...
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Retinoic Acid and PIC enhance tetanus vaccination

In studies with mice, Penn State researchers have shown that a combination of Retinoic Acid and PIC, a synthetic ...
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Epigenetic activity silences Rb2/p130 gene in lung cancer and retinoblastoma cells

The attaching of methyl--or chemical--groups onto DNA sequences within the tumor suppressing gene Rb2/p130 can cause the gene to cease ...
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PSA remains the best indicator of prostate cancer recurrence after surgery

A Johns Hopkins study of more than 2,000 men confirms that PSA remains the best measure of the likelihood of ...
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Postmenopausal women, consumption of soy may reduce risk of fracture

A study, published in the Archives of Internal Medicine, found that postmenopausal women who consumed high daily levels of soy ...
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Genetic factors influence propensity to bone fractures in elderly

A study, published in the Archives of Internal Medicine, found that the importance of genetic factors in an elderly individual's ...
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Oral contraceptives linked to reduced risk of multiple sclerosis

A study, published in the Archives of Neurology, showed that over a three-year period, the risk of developing multiple sclerosis ...
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Gene MYC activates gene MTA1 involved in metastasis

The cancer gene MYC is among the most commonly overexpressed oncogenes in human cancers. Most human cancers demonstrate high levels of ...
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Bariatric surgery is a safe option for treating obese with coronary artery disease

Researchers at Mayo Clinic reported that bariatric surgery is a safe option for treating obese patients who have coronary artery ...
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TNKase before PCI associated to higher mortality

Preliminary results from the ASSENT-4 PCI ( Assessment of the Safety and Efficacy of a New Treatment Strategy for Acute ...
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Interferon does not affect duration of black hole lesions in multiple sclerosis

Although treatment with Interferon appears to reduce the formation of new areas of damage in the brains of patients with ...
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Atrial fibrillation linked to heavy drinking

Researchers at Beth Israel Deaconess Medical Center ( BIDMC ) has found that heavy alcohol consumption – 35 or more ...
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FDA Advisory Panel recommends Tarceva approval for pancreatic cancer

The FDA’s Oncologic Drug Advisory Committee ( ODAC ) voted 10 to 3 in favor of recommending approval of Tarceva ...
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ODAC recommends Revlimid for low to intermediate-1-risk MDS patients with deletion 5q chromosomal abnormality

The Oncologic Drugs Advisory Committee ( ODAC ) of the U.S. Food and Drug Administration ( FDA ) recommended approval ...
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Pargluva, an investigational oral treatment for type 2 diabetes

The FDA’s Endocrinologic and Metabolic Drugs Advisory Committee voted to recommend approval of Pargluva ( Muraglitazar ), an investigational ...
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Amantadine-resistant avian influenza viruses more common in Southeast Asia than North America

A study, done by investigators at St. Jude Children's Research Hospital, found that resistance to the antiviral drug Amantadine is ...
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PUMA protein coordinates the cell-suicide activities of p53

Investigators from St. Jude Children's Research Hospital have discovered how the activities of the protein p53 initiate signals that trigger ...
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Xinlay, FDA Advisory Committee does not recommend approval

The Oncology Drug Advisory Committee ( ODAC ) to the U.S. Food and Drug Administration ( FDA ) did not ...
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Prostate cancer, Xinlay does not demonstrate any clear evidence of clinical efficacy

U.S. Food and Drug Administration ( FDA ) staff report did not find clear evidence of effectiveness for Abbott Laboratories’ ...
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Candesartan prevents the development of diabetes in patients with heart failure

A secondary analysis of the Candesartan in Heart Failure Assessment of Reduction in Mortality and morbidity ( CHARM ) program ...
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Role of nuclear receptors in inflammatory responses

In a paper, published in the journal Cell, Christopher Glass, at the University of California, San Diego ( UCSD ) ...
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High levels of daily stress may reduce risk of breast cancer

A prospective cohort study found that high levels of daily stress appear to result in a lower risk of developing ...
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AML patients with 8;21 translocation: need for different therapy

A study compared acute myeloid leukemia ( AML ) patients whose cancer cells showed chromosome changes known as the 8;21 ...
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Depression may worsen heart failure

A research suggests that depression may hasten the progression of heart disease by increasing the levels of a key protein ...
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AMD-3100 may help cancer patients who need stem cell transplants

AMD-3100, a new drug, may help cancer patients mobilize the cells necessary to restore their blood-forming system after high-dose chemotherapy, ...
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MRSA strains found to be increasingly deadly

A study has shown for the first time that strains of antibiotic-resistant Staphylococcus aureus bacteria are more deadly and better ...
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Prions convert healthy protein into abnormal protein

Researchers at the Brown Medical School have figured out the fate of healthy protein when it comes in contact with ...
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TORC2, key regulator of glucose production in liver cells

Researchers at the Salk Institute for Biological Studies discovered a key cellular switch that controls glucose production in liver cells. ...
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Role of cannabinoid receptors in alcohol abuse

A research, which was conducted at the U.S. Department of Energy’s Brookhaven National Laboratory, confirms a genetic basis for susceptibility ...
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ELISA II trial, better results with triple antiplatelet pre-treatment in patients with non-ST segment elevation acute coronary syndromes

Aspirin and Clopidogrel ( Plavix ) are platelet antiaggregant drugs widely used and proven to be effective in the treatment ...
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ACTIVE-W trial discontinued, a clear benefit in favour of Warfarin

Study treatments for the ACTIVE W trial of the ACTIVE ( Atrial Fibrillation Clopidogrel Trial with Irbesartan for Prevention of ...
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Folic acid in grains has reduced birth defects

Folic acid fortification of grain foods has produced a one-third decline in serious birth defects of the brain and spine, ...
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Parkinson's disease, DJ-1 gene plays critical roles in the survival of dopaminergic neurons

It is assumed that there is a relationship between agricultural chemicals and Parkinson's disease. Two groups of researchers, one led ...
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Prostate cancer, some of the improvement in survival rates may be due to a shift in the classification

Some of the improvement in prostate cancer survival rates over the past decade may be due to a shift in ...
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Breast cancer, an aromatase inhibitor, Letrozole, improves survival for some patients, reduces metastasis

The complete analysis of data from a trial of the drug Letrozole ( Femara ) confirms earlier reports that the ...
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Breast cancer, cardiotoxicity related to the use of Herceptin

Genentech, Inc. informed about an updated cardiotoxicity information related to the use of Herceptin ( Trastuzumab ), obtained from the ...
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Severe hypoglycemia is rare after islet transplantation

An analysis of outcomes in 138 patients who received an islet transplant for poorly controlled type 1 diabetes, showed that ...
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Anthrax, lethal toxin paralyzes neutrophils

Researchers at the University of Florida have uncovered how the inhaled form of anthrax disarms bacteria-fighting white blood cells before ...
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Markers of brain cell development may help success of stem cell transplants

Four sugar-coated faces made by stem cells as they differentiate into brain cells during development have been identified by researchers. These ...
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SPECT/CT to track migration of stem cells used to treat damaged hearts

Researchers from the Johns Hopkins Department of Radiology and Institute of Cell Engineering have used a non-invasive imaging technique, called ...
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Endotoxins in the household environment may trigger asthma symptoms

Bacteria lurking in household dust produce chemicals that may trigger asthma and asthma-related symptoms such as wheezing. These bacterial chemicals, ...
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Smoking damages key regulatory enzyme in the lung

A study, published in the Journal of Nuclear Medicine, found that smoking appears to reduce a key enzyme in the ...
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FDA says that review of Meridia NDA followed standard procedures

The U.S. Food and Drug Administration's ( FDA ) has denied Public Citizen's petition against Meridia ( Sibutramine ), but ...
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Metabolic syndrome, a cluster of metabolic abnormalities

The metabolic syndrome is a cluster of metabolic abnormalities with abdominal obesity at its centre. Although all forms of obesity ...
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Mycophenolate Mofetil may be effective in controlling inflammatory eye diseases

A study by researchers at Johns Hopkins’ Wilmer Eye Institute, showed that immunosuppressive drug Mycophenolate Mofetil ( CellCept ), used ...
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Amlodipine-based regimen reduces cardiovascular events better than standard tretament

The results of a randomised trial, published in The Lancet, demonstrated that a combination of modern anti-hypertensive drugs can reduce ...
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Coronary angioplasty, Plavix reduces risk of cardiovascular events and death

Use of the antiplatelet drug Clopidogrel ( Plavix ) before a coronary angioplasty reduced the risk of cardiovascular death, heart ...
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Inactivation of Chk1 contributes to the antitumor activity of Campthothecin

Researchers at The Burnham Institute found that a cell-cycle checkpoint protein, known to be activated by an important class of ...
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Fitness can reduce men’s deaths from heart disease

A study, published in the Circulation: Journal of the American Heart Association, shows that, regardless of cholesterol levels, men can ...
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Is rheumatoid arthritis becoming milder ?

The course of rheumatoid arthritis ( RA ) can vary considerably, from mild to crippling, and is difficult to predict. ...
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Estrogen deprivation and joint pain

Women treated with aromatase inhibitors often experience joint pain and musculoskeletal aching --severe enough, in some cases, to make them ...
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Multiple myeloma, Revlimid and Dexamethasone show promise

Researchers at the Mayo Clinic Cancer Center demonstrated that combination therapy with Lenalidomide ( Revlimid ) and Dexamethasone looks like ...
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FDA approves Fluarix, a flu vaccine for adults

The FDA ( Food and Drug Administration ) approved Fluarix, an influenza vaccine for adults that contains inactivated virus. Fluarix ...
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Suicidality in pediatric and adult patients treated with antidepressants

According to U.S. Food and Drug Administration ( FDA ), all patients being treated with any type of antidepressant for ...
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Heavy impact of Chlamydia on U.S. men and women, particularly young people

Centers for Disease Control and Prevention ( CDC ) data showed a heavy burden of chlamydia in young women and ...
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Once weekly Exenatide LAR improves glucose control

The study was designed to assess the safety, tolerability and pharmacokinetics of Exenatide ( Byetta ) LAR (long-acting release ) ...
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Advanced breast cancer, Taxotere more effective than Paclitaxel

The treatment with Docetaxel ( Taxotere ) significantly improved overall survival and median time to disease progression compared with Paclitaxel ...
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Macrophages kill bacteria, but not always

Macrophages are effective weapons used by our immune system to absorb and digest pathogenic intruders. Cell biologists at the University ...
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ABIN-1 in the treatment of liver disorders

Researchers at the Flanders Interuniversity Institute for Biotechnology ( VIB ) connected to Ghent University, have discovered the function of ...
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Most chronic hepatitis C patients will develop cirrhosis in later life

A study, published in the American Gastroenterological Association ( AGA ) journal Clinical Gastroenterology and Hepatology, showed that nearly ...
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Mutation in BRAC2 gene increases risk of several cancers in men

A genetic mutation implicated in an increased risk of breast and ovarian cancers also significantly increases the risk of pancreatic ...
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Dye predicts which pre-malignant lesions are likely to advance toward oral cancers

Canadian researchers have discovered a way to use a simple dye as a litmus test to identify abnormal areas of ...
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Pomegranate fruit extracts can block enzymes that contribute to osteoarthritis

A study, published in the Journal of Nutrition, carried out by researchers at Case Western Reserve University School of Medicine, ...
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People with inflammatory bowel disease are more prone to developing severe disorders of the respiratory and nervous systems

Two studies published in the American Gastroenterological Association ( AGA ) journal Gastroenterology, found an increase in the prevalence of ...
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New low-dose oral contraceptive with Drospirenone in premenstrual dysphoric disorder

A multicenter study, led by researchers at Yale School of Medicine, showed for a low dose oral contraceptive with Drospirenone, ...
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Olive Oil, Oleocanthal is a natural anti-inflammatory agent

Researchers from the Monell Chemical Senses Center and collaborators at the University of Pennsylvania, The University of the Sciences in ...
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Gene connected to centronuclear myopathy discovered

Researchers at University of Texas Southwestern Medical Center have discovered a gene that may play a role in a rare ...
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Human genomic response to inflammation tracked

A study by researchers at University of Florida ( UF ), published in the journal Nature, showed more than ...
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Chimp genome will allow to identify advantageous changes in human genetic code

Comparing the human genome to the chimpanzee genome will allow researchers to identify changes in the human genetic code so ...
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Soy, limited evidence for health impacts

The available studies on the health impacts of soy were limited in number, of poor quality, or their duration was ...
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Test detects infectious prions in blood

Researchers at the University of Texas Medical Branch at Galveston ( UTMB ) have found a way to detect in ...
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ActoPlus met approved by the FDA for type 2 diabetes

FDA ( U.S. Food and Drug Administration ) has approved the New Drug Application ( NDA ) for ActoPlus met ...
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GeoForm ring for heart failure patients with mitral valve problems

A device, invented at the University of Michigan Cardiovascular Center, offers a new treatment option for people with heart failure. ...
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Vagus nerve stimulation is effective in treating children with epilepsy

As an alternative to medication, the FDA approved implantation of a vagus nerve stimulator ( VNS ) in patients older ...
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Meridia, FDA says the benefits outweigh the risks

The FDA ( US Food and Drug Administration ) has rejected a petition to ban the sale of Meridia, an ...
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Coffee is a good source of antioxidants

Researchers at the University of Scranton found that coffee is the number one source of antioxidants in the U.S. diet. “ ...
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First production of human monoclonal antibodies in chicken eggs

Origen Therapeutics, a biotechnology company developing product opportunities arising from avian transgenic animal technology, announced the first published scientific ...
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Statins within first 24 hours after heart attack reduce mortality

Researchers at UCLA ( University of California- Los Angeles ) found that early treatment with a statin, a cholesterol ...
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Bypass surgery, Aspirin associated with lower mortality, but doesn’t raise bleeding risk

A study by Mayo Clinic researchers provides further evidence of Aspirin’s benefits for patients with heart disease and suggests they ...
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Magnetic nanoparticles based on metallic iron for potential cancer treatment

Researchers at Virginia Commonwealth University have created highly magnetized nanoparticles based on metallic iron that could be used in a ...
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Role of GCN2 in long-term memory

Researchers has discovered that GCN2, a protein in cells that inhibits the conversion of new information into long-term memory, may ...
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Caloric restriction may add a few years to a human life span

According to study by University of California - Los Angeles ( UCLA ) researchers, severely restricting calories over decades may ...
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Bioterrorism: anthrax test, developed by Army and CDC, receives FDA approval

FDA ( Food and Drug Administration ) has cleared a method for identifying Bacillus anthracis, the causative agent of anthrax, ...
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